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The mitochondrion of Plasmodium falciparum is required for cellular acetyl-CoA metabolism and protein acetylation.
Proc Natl Acad Sci U S A. 2023 Apr 25;120(17):e2210929120. doi: 10.1073/pnas.2210929120. Epub 2023 Apr 17.
Proc Natl Acad Sci U S A. 2023.
PMID: 37068227
Free PMC article.
Chemogenomics identifies acetyl-coenzyme A synthetase as a target for malaria treatment and prevention.
Summers RL, Pasaje CFA, Pisco JP, Striepen J, Luth MR, Kumpornsin K, Carpenter EF, Munro JT, Lin D, Plater A, Punekar AS, Shepherd AM, Shepherd SM, Vanaerschot M, Murithi JM, Rubiano K, Akidil A, Ottilie S, Mittal N, Dilmore AH, Won M, Mandt REK, McGowen K, Owen E, Walpole C, Llinás M, Lee MCS, Winzeler EA, Fidock DA, Gilbert IH, Wirth DF, Niles JC, Baragaña B, Lukens AK.
Summers RL, et al. Among authors: munro jt.
Cell Chem Biol. 2022 Feb 17;29(2):191-201.e8. doi: 10.1016/j.chembiol.2021.07.010. Epub 2021 Aug 3.
Cell Chem Biol. 2022.
PMID: 34348113
Free PMC article.
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