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POLG genotype influences degree of mitochondrial dysfunction in iPSC derived neural progenitors, but not the parent iPSC or derived glia.
Exp Neurol. 2023 Jul;365:114429. doi: 10.1016/j.expneurol.2023.114429. Epub 2023 Apr 25.
Exp Neurol. 2023.
PMID: 37105450
Free article.
Comparing the mitochondrial signatures in ESCs and iPSCs and their neural derivations.
Kristiansen CK, Chen A, Høyland LE, Ziegler M, Sullivan GJ, Bindoff LA, Liang KX.
Kristiansen CK, et al. Among authors: hoyland le.
Cell Cycle. 2022 Oct;21(20):2206-2221. doi: 10.1080/15384101.2022.2092185. Epub 2022 Jul 10.
Cell Cycle. 2022.
PMID: 35815665
Free PMC article.
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Disease-specific phenotypes in iPSC-derived neural stem cells with POLG mutations.
Liang KX, Kristiansen CK, Mostafavi S, Vatne GH, Zantingh GA, Kianian A, Tzoulis C, Høyland LE, Ziegler M, Perez RM, Furriol J, Zhang Z, Balafkan N, Hong Y, Siller R, Sullivan GJ, Bindoff LA.
Liang KX, et al. Among authors: hoyland le.
EMBO Mol Med. 2020 Oct 7;12(10):e12146. doi: 10.15252/emmm.202012146. Epub 2020 Aug 25.
EMBO Mol Med. 2020.
PMID: 32840960
Free PMC article.
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POLG mutations lead to abnormal mitochondrial remodeling during neural differentiation of human pluripotent stem cells via SIRT3/AMPK pathway inhibition.
Chen A, Kristiansen CK, Høyland LE, Ziegler M, Wang J, Sullivan GJ, Li X, Bindoff LA, Liang KX.
Chen A, et al. Among authors: hoyland le.
Cell Cycle. 2022 Jun;21(11):1178-1193. doi: 10.1080/15384101.2022.2044136. Epub 2022 Mar 17.
Cell Cycle. 2022.
PMID: 35298342
Free PMC article.
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