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Rational drug design and the discovery of the delta2-1,2,3-triazolines, a unique class of anticonvulsant and antiischemic agents.
Kadaba PK. Kadaba PK. Curr Med Chem. 2003 Oct;10(20):2081-108. doi: 10.2174/0929867033456765. Curr Med Chem. 2003. PMID: 12871087 Review.
While an active primary beta-amino alcohol metabolite from the parent prodrug acts as an N-methyl-D-aspartate (NMDA)/MK -801 receptor antagonist, the parent triazoline impairs the presynaptic release of L-Glu. ...
While an active primary beta-amino alcohol metabolite from the parent prodrug acts as an N-methyl-D-aspartate (NMDA)/MK -801 receptor …
Understanding People With Chronic Pain Who Use a Cognitive Behavioral Therapy-Based Artificial Intelligence Mental Health App (Wysa): Mixed Methods Retrospective Observational Study.
Meheli S, Sinha C, Kadaba M. Meheli S, et al. Among authors: kadaba m. JMIR Hum Factors. 2022 Apr 27;9(2):e35671. doi: 10.2196/35671. JMIR Hum Factors. 2022. PMID: 35314422 Free PMC article.
Furthermore, users with pre-post assessments during the study period were found to have significant improvements in group means for both PHQ-9 and GAD-7 symptom scores, with a medium effect size (Cohen d=0.60-0.61). CONCLUSIONS: The findings indicate that users look for to …
Furthermore, users with pre-post assessments during the study period were found to have significant improvements in group means for both PHQ …
Milacemide and memory.
Kadaba PK. Kadaba PK. Neurology. 1992 Jul;42(7):1434-5. doi: 10.1212/wnl.42.7.1434-b. Neurology. 1992. PMID: 1535694 No abstract available.
Recursive estimation of images using non-Gaussian autoregressive models.
Kadaba SR, Gelfand SB, Kashyap RL. Kadaba SR, et al. IEEE Trans Image Process. 1998;7(10):1439-52. doi: 10.1109/83.718484. IEEE Trans Image Process. 1998. PMID: 18276210
The goal is to find a recursive algorithm to compute a near minimum mean square error (MMSE) estimate of each pixel of the scene using a fixed lookahead of D rows and D columns of the observations. Our method is based on a simple approximation that makes possible th …
The goal is to find a recursive algorithm to compute a near minimum mean square error (MMSE) estimate of each pixel of the scene using a fix …
Chiral liquid chromatography resolution and stereoselective pharmacokinetic study of the enantiomers of a novel anticonvulsant, N-(4-chlorophenyl)-1-(4-pyridyl)ethylamine, in rats.
Tao X, Kadaba PK, Nnane IP. Tao X, et al. Among authors: kadaba pk. J Chromatogr B Analyt Technol Biomed Life Sci. 2003 Oct 25;796(1):35-44. doi: 10.1016/s1570-0232(03)00611-1. J Chromatogr B Analyt Technol Biomed Life Sci. 2003. PMID: 14552814
After extraction of the plasma samples with ethyl acetate, the separation was accomplished by an HPLC system consisting of a Chirex chiral column (250 mm x 4.6 mm i.d.) and a mobile phase of hexane:ethanol:tetrahydrofuran (280:20:40 (v/v)) containing trifluroacetic acid (0 …
After extraction of the plasma samples with ethyl acetate, the separation was accomplished by an HPLC system consisting of a Chirex chiral c …
Triazolines--XXVII. delta2-1,2,3-triazoline anticonvulsants: novel 'built-in' heterocyclic prodrugs with a unique 'dual-action' mechanism for impairing excitatory amino acid L-glutamate neurotransmission.
Kadaba PK, Stevenson PJ, P-Nnane I, Damani LA. Kadaba PK, et al. Bioorg Med Chem. 1996 Feb;4(2):165-78. doi: 10.1016/0968-0896(95)00168-9. Bioorg Med Chem. 1996. PMID: 8814876
While an active beta-amino alcohol metabolite, 2a, from the parent prodrug acts as an N-methyl-D-aspartate (NMDA)/MK-801 receptor antagonist, the parent triazoline impairs the presynaptic release of L-Glu. ...
While an active beta-amino alcohol metabolite, 2a, from the parent prodrug acts as an N-methyl-D-aspartate (NMDA)/MK-801 receptor ant …
Triazolines. XXIII. High-performance liquid chromatographic assay in rat blood for a novel triazoline anticonvulsant (ADD17014).
Stevenson PJ, Hamelijnck MA, Kadaba PK, Damani LA. Stevenson PJ, et al. Among authors: kadaba pk. J Chromatogr. 1991 Feb 15;563(2):419-26. J Chromatogr. 1991. PMID: 2056006
Compound I and the internal standard (dipyridamole) were extracted into diethyl ether (5 ml) from alkalinised blood (0.25 ml of blood plus 0.75 ml of pH 10.7 buffer), with extractability nearing 100% under these conditions. The assay is based on reversed-phase HPLC (25 cm x 0.46 …
Compound I and the internal standard (dipyridamole) were extracted into diethyl ether (5 ml) from alkalinised blood (0.25 ml of blood plus 0 …
Bayesian decision feedback for segmentation of binary images.
Kadaba SR, Gelfand SB, Kashyap RL. Kadaba SR, et al. IEEE Trans Image Process. 1996;5(7):1163-78. doi: 10.1109/83.502395. IEEE Trans Image Process. 1996. PMID: 18285204
The goal is to find a recursive algorithm to compute the maximum a posteriori (MAP) estimate of each pixel of the scene using a fixed lookahead of D rows and D columns of the observations. First, this MAP fixed-lag estimation problem is set up and the corresponding …
The goal is to find a recursive algorithm to compute the maximum a posteriori (MAP) estimate of each pixel of the scene using a fixed lookah …