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Pre-encoded responsiveness to type I interferon in the peripheral immune system defines outcome of PD1 blockade therapy.
Boukhaled GM, Gadalla R, Elsaesser HJ, Abd-Rabbo D, Quevedo R, Yang SYC, Guo M, Wang BX, Noamani B, Gray D, Lau SCM, Taylor K, Aung K, Spreafico A, Hansen AR, Saibil SD, Hirano N, Guidos C, Pugh TJ, McGaha TL, Ohashi PS, Sacher AG, Butler MO, Brooks DG. Boukhaled GM, et al. Nat Immunol. 2022 Aug;23(8):1273-1283. doi: 10.1038/s41590-022-01262-7. Epub 2022 Jul 14. Nat Immunol. 2022. PMID: 35835962
Opposing Roles of Type I Interferons in Cancer Immunity.
Boukhaled GM, Harding S, Brooks DG. Boukhaled GM, et al. Annu Rev Pathol. 2021 Jan 24;16:167-198. doi: 10.1146/annurev-pathol-031920-093932. Epub 2020 Dec 2. Annu Rev Pathol. 2021. PMID: 33264572 Free PMC article. Review.
Molecular, metabolic and functional CD4 T cell paralysis impedes tumor control.
Guo M, Abd-Rabbo D, Bertol B, Carew M, Lukhele S, Snell LM, Xu W, Boukhaled GM, Elsaesser H, Halaby MJ, Hirano N, McGaha TL, Brooks DG. Guo M, et al. Among authors: boukhaled gm. bioRxiv [Preprint]. 2023 Apr 17:2023.04.15.536946. doi: 10.1101/2023.04.15.536946. bioRxiv. 2023. PMID: 37131587 Free PMC article. Updated. Preprint.
IL-2 produced by HBV-specific T cells as a biomarker of viral control and predictor of response to PD-1 therapy across clinical phases of chronic hepatitis B.
Chua C, Salimzadeh L, Ma AT, Adeyi OA, Seo H, Boukhaled GM, Mehrotra A, Patel A, Ferrando-Martinez S, Robbins SH, La D, Wong D, Janssen HLA, Brooks DG, Feld JJ, Gehring AJ. Chua C, et al. Among authors: boukhaled gm. Hepatol Commun. 2023 Dec 7;7(12):e0337. doi: 10.1097/HC9.0000000000000337. eCollection 2023 Dec 1. Hepatol Commun. 2023. PMID: 38055623 Free PMC article.
DNA hypomethylating agents increase activation and cytolytic activity of CD8+ T cells.
Loo Yau H, Bell E, Ettayebi I, de Almeida FC, Boukhaled GM, Shen SY, Allard D, Morancho B, Marhon SA, Ishak CA, Gonzaga IM, da Silva Medina T, Singhania R, Chakravarthy A, Chen R, Mehdipour P, Pommey S, Klein C, Amarante-Mendes GP, Roulois D, Arribas J, Stagg J, Brooks DG, De Carvalho DD. Loo Yau H, et al. Among authors: boukhaled gm. Mol Cell. 2021 Apr 1;81(7):1469-1483.e8. doi: 10.1016/j.molcel.2021.01.038. Epub 2021 Feb 19. Mol Cell. 2021. PMID: 33609448 Free article.
13 results