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The Traumatic Inoculation Process Affects TSPO Radioligand Uptake in Experimental Orthotopic Glioblastoma.
Gold L, Barci E, Brendel M, Orth M, Cheng J, Kirchleitner SV, Bartos LM, Pötter D, Kirchner MA, Unterrainer LM, Kaiser L, Ziegler S, Weidner L, Riemenschneider MJ, Unterrainer M, Belka C, Tonn JC, Bartenstein P, Niyazi M, von Baumgarten L, Kälin RE, Glass R, Lauber K, Albert NL, Holzgreve A. Gold L, et al. Among authors: weidner l. Biomedicines. 2024 Jan 15;12(1):188. doi: 10.3390/biomedicines12010188. Biomedicines. 2024. PMID: 38255293 Free PMC article.
Translocator protein (18kDA) (TSPO) marks mesenchymal glioblastoma cell populations characterized by elevated numbers of tumor-associated macrophages.
Weidner L, Lorenz J, Quach S, Braun FK, Rothhammer-Hampl T, Ammer LM, Vollmann-Zwerenz A, Bartos LM, Dekorsy FJ, Holzgreve A, Kirchleitner SV, Thon N, Greve T, Ruf V, Herms J, Bader S, Milenkovic VM, von Baumgarten L, Menevse AN, Hussein A, Sax J, Wetzel CH, Rupprecht R, Proescholdt M, Schmidt NO, Beckhove P, Hau P, Tonn JC, Bartenstein P, Brendel M, Albert NL, Riemenschneider MJ. Weidner L, et al. Acta Neuropathol Commun. 2023 Sep 11;11(1):147. doi: 10.1186/s40478-023-01651-5. Acta Neuropathol Commun. 2023. PMID: 37697350 Free PMC article.
TSPO acts as an immune resistance gene involved in the T cell mediated immune control of glioblastoma.
Menevse AN, Ammer LM, Vollmann-Zwerenz A, Kupczyk M, Lorenz J, Weidner L, Hussein A, Sax J, Mühlbauer J, Heuschneider N, Rohrmus C, Mai LS, Jachnik B, Stamova S, Volpin V, Durst FC, Sorrentino A, Xydia M, Milenkovic VM, Bader S, Braun FK, Wetzel C, Albert NL, Tonn JC, Bartenstein P, Proescholdt M, Schmidt NO, Linker RA, Riemenschneider MJ, Beckhove P, Hau P. Menevse AN, et al. Among authors: weidner l. Acta Neuropathol Commun. 2023 May 8;11(1):75. doi: 10.1186/s40478-023-01550-9. Acta Neuropathol Commun. 2023. PMID: 37158962 Free PMC article.
TSPO PET signal using [18F]GE180 is associated with survival in recurrent gliomas.
Quach S, Holzgreve A, Kaiser L, Unterrainer M, Dekorsy FJ, Nelwan DV, Bartos LM, Kirchleitner SV, Weller J, Weidner L, Niyazi M, Ruf VC, Herms J, Stöcklein S, Wetzel C, Riemenschneider MJ, V Baumgarten L, Thon N, Brendel M, Rupprecht R, Bartenstein P, Tonn JC, Albert NL. Quach S, et al. Among authors: weidner l. Eur J Nucl Med Mol Imaging. 2023 Feb;50(3):859-869. doi: 10.1007/s00259-022-06006-1. Epub 2022 Nov 4. Eur J Nucl Med Mol Imaging. 2023. PMID: 36329288 Free PMC article.
L-type amino acid transporter (LAT) 1 expression in 18F-FET-negative gliomas.
Vettermann FJ, Diekmann C, Weidner L, Unterrainer M, Suchorska B, Ruf V, Dorostkar M, Wenter V, Herms J, Tonn JC, Bartenstein P, Riemenschneider MJ, Albert NL. Vettermann FJ, et al. Among authors: weidner l. EJNMMI Res. 2021 Dec 14;11(1):124. doi: 10.1186/s13550-021-00865-9. EJNMMI Res. 2021. PMID: 34905134 Free PMC article.
Longitudinal [18F]GE-180 PET Imaging Facilitates In Vivo Monitoring of TSPO Expression in the GL261 Glioblastoma Mouse Model.
Holzgreve A, Pötter D, Brendel M, Orth M, Weidner L, Gold L, Kirchner MA, Bartos LM, Unterrainer LM, Unterrainer M, Steiger K, von Baumgarten L, Niyazi M, Belka C, Bartenstein P, Riemenschneider MJ, Lauber K, Albert NL. Holzgreve A, et al. Among authors: weidner l. Biomedicines. 2022 Mar 22;10(4):738. doi: 10.3390/biomedicines10040738. Biomedicines. 2022. PMID: 35453488 Free PMC article.
18 kDa translocator protein positron emission tomography facilitates early and robust tumor detection in the immunocompetent SB28 glioblastoma mouse model.
Bartos LM, Kirchleitner SV, Blobner J, Wind K, Kunze LH, Holzgreve A, Gold L, Zatcepin A, Kolabas ZI, Ulukaya S, Weidner L, Quach S, Messerer D, Bartenstein P, Tonn JC, Riemenschneider MJ, Ziegler S, von Baumgarten L, Albert NL, Brendel M. Bartos LM, et al. Among authors: weidner l. Front Med (Lausanne). 2022 Oct 17;9:992993. doi: 10.3389/fmed.2022.992993. eCollection 2022. Front Med (Lausanne). 2022. PMID: 36325388 Free PMC article.
Genome-wide association meta-analysis for early age-related macular degeneration highlights novel loci and insights for advanced disease.
Winkler TW, Grassmann F, Brandl C, Kiel C, Günther F, Strunz T, Weidner L, Zimmermann ME, Korb CA, Poplawski A, Schuster AK, Müller-Nurasyid M, Peters A, Rauscher FG, Elze T, Horn K, Scholz M, Cañadas-Garre M, McKnight AJ, Quinn N, Hogg RE, Küchenhoff H, Heid IM, Stark KJ, Weber BHF. Winkler TW, et al. Among authors: weidner l. BMC Med Genomics. 2020 Aug 26;13(1):120. doi: 10.1186/s12920-020-00760-7. BMC Med Genomics. 2020. PMID: 32843070 Free PMC article.