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SKP2 drives the sensitivity to neddylation inhibitors and cisplatin in malignant pleural mesothelioma.
Salaroglio IC, Belisario DC, Bironzo P, Ananthanarayanan P, Ricci L, Digiovanni S, Fontana S, Napoli F, Sandri A, Facolmatà C, Libener R, Comunanza V, Grosso F, Gazzano E, Leo F, Taulli R, Bussolino F, Righi L, Papotti MG, Novello S, Scagliotti GV, Riganti C, Kopecka J. Salaroglio IC, et al. Among authors: bussolino f. J Exp Clin Cancer Res. 2022 Feb 23;41(1):75. doi: 10.1186/s13046-022-02284-7. J Exp Clin Cancer Res. 2022. PMID: 35197103 Free PMC article.
METHODS: Here, we investigated the role of the E3-ubiquitin ligase SKP/Cullin/F-box (SCF) complex in cell cycle progression, endoplasmic reticulum (ER)/proteostatic stress and ICD in MPM, and the therapeutic potential of the neddylation/SCF complex inhibitor MLN4924/Pevone …
METHODS: Here, we investigated the role of the E3-ubiquitin ligase SKP/Cullin/F-box (SCF) complex in cell cycle progression, endoplas …
Sema3F (Semaphorin 3F) Selectively Drives an Extraembryonic Proangiogenic Program.
Regano D, Visintin A, Clapero F, Bussolino F, Valdembri D, Maione F, Serini G, Giraudo E. Regano D, et al. Among authors: bussolino f. Arterioscler Thromb Vasc Biol. 2017 Sep;37(9):1710-1721. doi: 10.1161/ATVBAHA.117.308226. Epub 2017 Jul 20. Arterioscler Thromb Vasc Biol. 2017. PMID: 28729362 Free PMC article.
SiCILIA-Silicon Carbide Detectors for Intense Luminosity Investigations and Applications.
Tudisco S, La Via F, Agodi C, Altana C, Borghi G, Boscardin M, Bussolino G, Calcagno L, Camarda M, Cappuzzello F, Carbone D, Cascino S, Casini G, Cavallaro M, Ciampi C, Cirrone G, Cuttone G, Fazzi A, Giove D, Gorini G, Labate L, Lanzalone G, Litrico G, Longo G, Lo Presti D, Mauceri M, Modica R, Moschetti M, Muoio A, Musumeci F, Pasquali G, Petringa G, Piluso N, Poggi G, Privitera S, Puglia S, Puglisi V, Rebai M, Ronchin S, Santangelo A, Stefanini A, Trifirò A, Zimbone M. Tudisco S, et al. Among authors: bussolino g. Sensors (Basel). 2018 Jul 15;18(7):2289. doi: 10.3390/s18072289. Sensors (Basel). 2018. PMID: 30011947 Free PMC article.
Stimulation of the Na+/H+ exchanger in human endothelial cells activated by granulocyte- and granulocyte-macrophage-colony-stimulating factor. Evidence for a role in proliferation and migration.
Bussolino F, Wang JM, Turrini F, Alessi D, Ghigo D, Costamagna C, Pescarmona G, Mantovani A, Bosia A. Bussolino F, et al. J Biol Chem. 1989 Nov 5;264(31):18284-7. J Biol Chem. 1989. PMID: 2478542 Free article.
It has been shown that human endothelial cells (HEC) are stimulated to migrate and proliferate by granulocyte (G)- and granulocyte-macrophage (GM)-colony-stimulating factor (CSF) (Bussolino, F., Wang, J. M., Defilipii, P. Turrini, F., Sanavio, F., Edgell, C.. …
It has been shown that human endothelial cells (HEC) are stimulated to migrate and proliferate by granulocyte (G)- and granulocyte-macrophag …
Clinical-Molecular Prospective Cohort Study in Non-Small Cell Lung Cancer (PROMOLE study): A Comprehensive Approach to Identify New Predictive Markers of Pharmacological Response.
Bironzo P, Primo L, Novello S, Righi L, Candeloro S, Manganaro L, Bussolino F, Pirri F, Scagliotti GV. Bironzo P, et al. Among authors: bussolino f. Clin Lung Cancer. 2022 Sep;23(6):e347-e352. doi: 10.1016/j.cllc.2022.05.007. Epub 2022 May 11. Clin Lung Cancer. 2022. PMID: 35697558
The platform will include: a) digital patient data collection; b) whole NGS molecular analyses (exome, transcriptome, methylome) for tumor characterization; c) exploitation and collection of organoids from tissue patients; d) Surface Amplified Raman Spectroscopy; e) microfluidic- …
The platform will include: a) digital patient data collection; b) whole NGS molecular analyses (exome, transcriptome, methylome) for tumor c …
Small GTPase Rab5 participates in chromosome congression and regulates localization of the centromere-associated protein CENP-F to kinetochores.
Serio G, Margaria V, Jensen S, Oldani A, Bartek J, Bussolino F, Lanzetti L. Serio G, et al. Among authors: bussolino f. Proc Natl Acad Sci U S A. 2011 Oct 18;108(42):17337-42. doi: 10.1073/pnas.1103516108. Epub 2011 Oct 10. Proc Natl Acad Sci U S A. 2011. PMID: 21987812 Free PMC article.
We found that Rab5 forms a complex with a subset of CENP-F in mitotic cells and regulates the kinetics of release of CENP-F from the nuclear envelope and its accumulation on kinetochores. Simultaneous depletion of both Rab5 and CENP-F recapitulated the mitoti …
We found that Rab5 forms a complex with a subset of CENP-F in mitotic cells and regulates the kinetics of release of CENP-F fr …
MRCKα is activated by caspase cleavage to assemble an apical actin ring for epithelial cell extrusion.
Gagliardi PA, Somale D, Puliafito A, Chiaverina G, di Blasio L, Oneto M, Bianchini P, Bussolino F, Primo L. Gagliardi PA, et al. Among authors: bussolino f. J Cell Biol. 2018 Jan 2;217(1):231-249. doi: 10.1083/jcb.201703044. Epub 2017 Nov 21. J Cell Biol. 2018. PMID: 29162624 Free PMC article.
Caspase-mediated cleavage of myotonic dystrophy kinase-related CDC42-binding kinase-alpha (MRCKalpha) triggers a signaling pathway that leads to the assembly of EAAR that pulls actin bundles, resulting in the compaction and removal of the cell body. We provide a detailed portrait …
Caspase-mediated cleavage of myotonic dystrophy kinase-related CDC42-binding kinase-alpha (MRCKalpha) triggers a signaling pathway that lead …
Human endothelial cells are targets for platelet-activating factor (PAF). Activation of alpha and beta protein kinase C isozymes in endothelial cells stimulated by PAF.
Bussolino F, Silvagno F, Garbarino G, Costamagna C, Sanavio F, Arese M, Soldi R, Aglietta M, Pescarmona G, Camussi G, et al. Bussolino F, et al. J Biol Chem. 1994 Jan 28;269(4):2877-86. J Biol Chem. 1994. PMID: 7507929 Free article.
Exposure of confluent EC to PAF resulted in a rapid and concentration-dependent redistribution of PKC from cytosol to plasma-membrane, rearrangement of cytoskeleton (i.e. decrease in F-actin content and redistribution of vinculin), and finally increase in the transendothel …
Exposure of confluent EC to PAF resulted in a rapid and concentration-dependent redistribution of PKC from cytosol to plasma-membrane, rearr …
Platelet activating factor is elevated in cerebral spinal fluid and plasma of patients with relapsing-remitting multiple sclerosis.
Callea L, Arese M, Orlandini A, Bargnani C, Priori A, Bussolino F. Callea L, et al. Among authors: bussolino f. J Neuroimmunol. 1999 Feb 1;94(1-2):212-21. doi: 10.1016/s0165-5728(98)00246-x. J Neuroimmunol. 1999. PMID: 10376955
It was also found that both plasma (R2: 0.65) and CSF (R2:0.72) levels were correlated with the MRI number of gadolinium enhancing lesions, which are markers of blood-brain barrier (BBB) injury, whereas their peaks were not correlated with the MRI number of white matter lesions, …
It was also found that both plasma (R2: 0.65) and CSF (R2:0.72) levels were correlated with the MRI number of gadolinium enhancing lesions, …
Temporal and spatial modulation of Rho GTPases during in vitro formation of capillary vascular network. Adherens junctions and myosin light chain as targets of Rac1 and RhoA.
Cascone I, Giraudo E, Caccavari F, Napione L, Bertotti E, Collard JG, Serini G, Bussolino F. Cascone I, et al. Among authors: bussolino f. J Biol Chem. 2003 Dec 12;278(50):50702-13. doi: 10.1074/jbc.M307234200. Epub 2003 Sep 12. J Biol Chem. 2003. PMID: 12972426 Free article.
N17Rac1 reduces the shift of beta-catenin and vascular endothelial cadherin to Triton X-100-insoluble fraction and impairs beta-catenin distribution at adherens junctions, suggesting that Rac1 controls the dynamics of cadherin-catenin complex with F-actin. During the remod …
N17Rac1 reduces the shift of beta-catenin and vascular endothelial cadherin to Triton X-100-insoluble fraction and impairs beta-catenin dist …
13 results