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Spatially resolved transcriptomics reveals genes associated with the vulnerability of middle temporal gyrus in Alzheimer's disease.
Chen S, Chang Y, Li L, Acosta D, Li Y, Guo Q, Wang C, Turkes E, Morrison C, Julian D, Hester ME, Scharre DW, Santiskulvong C, Song SX, Plummer JT, Serrano GE, Beach TG, Duff KE, Ma Q, Fu H. Chen S, et al. Among authors: turkes e. Acta Neuropathol Commun. 2022 Dec 21;10(1):188. doi: 10.1186/s40478-022-01494-6. Acta Neuropathol Commun. 2022. PMID: 36544231 Free PMC article.
Using single-molecule fluorescent in situ hybridization, we validated the cell-type-specific expression of three novel DEGs (e.g., KIF5A, PAQR6, and SLC1A3) and eleven previously reported DEGs associated with AD pathology (i.e., amyloid beta plaques and intraneurona …
Using single-molecule fluorescent in situ hybridization, we validated the cell-type-specific expression of three novel DEGs (e.g., KI …
Data for a meta-analysis of the adaptive layer in adaptive large neighborhood search.
Turkeš R, Sörensen K, Hvattum LM, Barrena E, Chentli H, Coelho LC, Dayarian I, Grimault A, Gullhav AN, Iris Ç, Keskin M, Kiefer A, Lusby RM, Mauri GR, Monroy-Licht M, Parragh SN, Riquelme-Rodríguez JP, Santini A, Santos VGM, Thomas C. Turkeš R, et al. Data Brief. 2020 Nov 24;33:106568. doi: 10.1016/j.dib.2020.106568. eCollection 2020 Dec. Data Brief. 2020. PMID: 33304965 Free PMC article.
A total of 134 studies were identified through Google Scholar or personal e-mail correspondence with researchers in the domain, 63 of which fit a set of predefined eligibility criteria. ...
A total of 134 studies were identified through Google Scholar or personal e-mail correspondence with researchers in the domain, 63 of …
Molecular Docking Studies and Inhibition Properties of Some Antineoplastic Agents against Paraoxonase-I.
Demir Y, Türkeş C, Beydemir Ş. Demir Y, et al. Among authors: turkes c. Anticancer Agents Med Chem. 2020;20(7):887-896. doi: 10.2174/1871520620666200218110645. Anticancer Agents Med Chem. 2020. PMID: 32067621
OBJECTIVE: The current study aimed to contribute to this growing drug design field (i.e., medicine discovery and development) by analyzing enzyme-drug interactions. ...
OBJECTIVE: The current study aimed to contribute to this growing drug design field (i.e., medicine discovery and development) by anal …
Investigation of Potential Paraoxonase-I Inhibitors by Kinetic and Molecular Docking Studies: Chemotherapeutic Drugs.
Türkeş C. Türkeş C. Protein Pept Lett. 2019;26(6):392-402. doi: 10.2174/0929866526666190226162225. Protein Pept Lett. 2019. PMID: 30819074
BACKGROUND: Metabolic processes in living organisms are closely related to the catalytic activity of enzymes. Changes in enzyme activity cause various diseases e.g., neurological, cancer, metabolic and cardiovascular. Most of the current therapeutic drugs available in clin …
BACKGROUND: Metabolic processes in living organisms are closely related to the catalytic activity of enzymes. Changes in enzyme activity cau …
Novel spiroindoline derivatives targeting aldose reductase against diabetic complications: Bioactivity, cytotoxicity, and molecular modeling studies.
Güleç Ö, Türkeş C, Arslan M, Demir Y, Dincer B, Ece A, İrfan Küfrevioğlu Ö, Beydemir Ş. Güleç Ö, et al. Among authors: turkes c. Bioorg Chem. 2024 Apr;145:107221. doi: 10.1016/j.bioorg.2024.107221. Epub 2024 Feb 19. Bioorg Chem. 2024. PMID: 38387398
Despite significant developments in therapeutic strategies, Diabetes Mellitus remains an increasing concern, leading to various complications, e.g., cataracts, neuropathy, retinopathy, nephropathy, and several cardiovascular diseases. ...
Despite significant developments in therapeutic strategies, Diabetes Mellitus remains an increasing concern, leading to various complication …
Induction of heat shock proteins in B-cell exosomes.
Clayton A, Turkes A, Navabi H, Mason MD, Tabi Z. Clayton A, et al. Among authors: turkes a. J Cell Sci. 2005 Aug 15;118(Pt 16):3631-8. doi: 10.1242/jcs.02494. Epub 2005 Jul 26. J Cell Sci. 2005. PMID: 16046478
Stress also triggered a small increase in the quantity of exosomes produced [with a ratio of 1.245+/-0.07 to 1 (mean+/-s.e.m., n=20) of 3-hour-stress-exosomes to control-exosomes]. Flow-cytometric analysis of exosome-coated beads and immuno-precipitation of intact exosomes …
Stress also triggered a small increase in the quantity of exosomes produced [with a ratio of 1.245+/-0.07 to 1 (mean+/-s.e.m., n=20) …
Inhibition of Human Serum Paraoxonase-I with Antimycotic Drugs: In Vitro and In Silico Studies.
Türkeş C, Beydemir Ş. Türkeş C, et al. Appl Biochem Biotechnol. 2020 Jan;190(1):252-269. doi: 10.1007/s12010-019-03073-3. Epub 2019 Jul 24. Appl Biochem Biotechnol. 2020. PMID: 31342307
Therefore, enzyme inhibitors have an essential place in the drug design for numerous different sorts of diseases, i.e., cardiovascular, cancer, metabolic, and neurological. The purpose of the current study was to contribute to the growing drug discovery and development are …
Therefore, enzyme inhibitors have an essential place in the drug design for numerous different sorts of diseases, i.e., cardiovascula …