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Soluble pathogenic tau enters brain vascular endothelial cells and drives cellular senescence and brain microvascular dysfunction in a mouse model of tauopathy.
Hussong SA, Banh AQ, Van Skike CE, Dorigatti AO, Hernandez SF, Hart MJ, Ferran B, Makhlouf H, Gaczynska M, Osmulski PA, McAllen SA, Dineley KT, Ungvari Z, Perez VI, Kayed R, Galvan V. Hussong SA, et al. Among authors: dorigatti ao. Nat Commun. 2023 Apr 25;14(1):2367. doi: 10.1038/s41467-023-37840-y. Nat Commun. 2023. PMID: 37185259 Free PMC article.
Lifespan benefits for the combination of rapamycin plus acarbose and for captopril in genetically heterogeneous mice.
Strong R, Miller RA, Cheng CJ, Nelson JF, Gelfond J, Allani SK, Diaz V, Dorigatti AO, Dorigatti J, Fernandez E, Galecki A, Ginsburg B, Hamilton KL, Javors MA, Kornfeld K, Kaeberlein M, Kumar S, Lombard DB, Lopez-Cruzan M, Miller BF, Rabinovitch P, Reifsnyder P, Rosenthal NA, Bogue MA, Salmon AB, Suh Y, Verdin E, Weissbach H, Newman J, Maccchiarini F, Harrison DE. Strong R, et al. Aging Cell. 2022 Dec;21(12):e13724. doi: 10.1111/acel.13724. Epub 2022 Sep 30. Aging Cell. 2022. PMID: 36179270 Free PMC article.
Brain cellular senescence in mouse models of Alzheimer's disease.
Dorigatti AO, Riordan R, Yu Z, Ross G, Wang R, Reynolds-Lallement N, Magnusson K, Galvan V, Perez VI. Dorigatti AO, et al. Geroscience. 2022 Apr;44(2):1157-1168. doi: 10.1007/s11357-022-00531-5. Epub 2022 Mar 6. Geroscience. 2022. PMID: 35249206 Free PMC article.