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Disulfiram causes selective hypoxic cancer cell toxicity and radio-chemo-sensitization via redox cycling of copper.
Falls-Hubert KC, Butler AL, Gui K, Anderson M, Li M, Stolwijk JM, Rodman SN 3rd, Solst SR, Tomanek-Chalkley A, Searby CC, Sheffield VC, Sandfort V, Schmidt H, McCormick ML, Wels BR, Allen BG, Buettner GR, Schultz MK, Spitz DR. Falls-Hubert KC, et al. Among authors: solst sr. Free Radic Biol Med. 2020 Apr;150:1-11. doi: 10.1016/j.freeradbiomed.2020.01.186. Epub 2020 Feb 4. Free Radic Biol Med. 2020. PMID: 32032663 Free PMC article.
Auranofin Inhibition of Thioredoxin Reductase Sensitizes Lung Neuroendocrine Tumor Cells (NETs) and Small Cell Lung Cancer (SCLC) Cells to Sorafenib as well as Inhibiting SCLC Xenograft Growth.
Johnson SS, Liu D, Ewald JT, Robles-Planells C, Christensen KA, Bayanbold K, Wels BR, Solst SR, O'Dorisio MS, Allen BG, Menda Y, Spitz DR, Fath MA. Johnson SS, et al. Among authors: solst sr. bioRxiv [Preprint]. 2024 Jan 30:2023.05.07.539772. doi: 10.1101/2023.05.07.539772. bioRxiv. 2024. PMID: 37215042 Free PMC article. Preprint.
Disrupting Mitochondrial Pyruvate Uptake Directs Glutamine into the TCA Cycle away from Glutathione Synthesis and Impairs Hepatocellular Tumorigenesis.
Tompkins SC, Sheldon RD, Rauckhorst AJ, Noterman MF, Solst SR, Buchanan JL, Mapuskar KA, Pewa AD, Gray LR, Oonthonpan L, Sharma A, Scerbo DA, Dupuy AJ, Spitz DR, Taylor EB. Tompkins SC, et al. Among authors: solst sr. Cell Rep. 2019 Sep 3;28(10):2608-2619.e6. doi: 10.1016/j.celrep.2019.07.098. Cell Rep. 2019. PMID: 31484072 Free PMC article.
D-penicillamine combined with inhibitors of hydroperoxide metabolism enhances lung and breast cancer cell responses to radiation and carboplatin via H2O2-mediated oxidative stress.
Sciegienka SJ, Solst SR, Falls KC, Schoenfeld JD, Klinger AR, Ross NL, Rodman SN, Spitz DR, Fath MA. Sciegienka SJ, et al. Among authors: solst sr. Free Radic Biol Med. 2017 Jul;108:354-361. doi: 10.1016/j.freeradbiomed.2017.04.001. Epub 2017 Apr 5. Free Radic Biol Med. 2017. PMID: 28389407 Free PMC article.