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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1980 2
1981 2
1982 1
1984 4
1985 2
1987 3
1988 5
1989 4
1990 10
1991 10
1992 13
1993 18
1994 34
1995 37
1996 38
1997 43
1998 47
1999 65
2000 51
2001 73
2002 78
2003 129
2004 170
2005 156
2006 177
2007 193
2008 219
2009 239
2010 295
2011 321
2012 364
2013 431
2014 494
2015 548
2016 562
2017 645
2018 658
2019 744
2020 833
2021 874
2022 952
2023 925
2024 450

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9,697 results

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Page 1
Structural Mechanism for GSDMD Targeting by Autoprocessed Caspases in Pyroptosis.
Wang K, Sun Q, Zhong X, Zeng M, Zeng H, Shi X, Li Z, Wang Y, Zhao Q, Shao F, Ding J. Wang K, et al. Among authors: ding j. Cell. 2020 Mar 5;180(5):941-955.e20. doi: 10.1016/j.cell.2020.02.002. Epub 2020 Feb 27. Cell. 2020. PMID: 32109412 Free article.
In caspase-4/11-GSDMD-C complex crystal structures, the beta sheet organizes a hydrophobic GSDMD-binding interface that is only possible for p10-form caspase-4/11. The binding promotes dimerization-mediated caspase activation, rendering a cleavage independently of t …
In caspase-4/11-GSDMD-C complex crystal structures, the beta sheet organizes a hydrophobic GSDMD-binding interface that is only possi …
The transcription factor ZEB2 drives the formation of age-associated B cells.
Dai D, Gu S, Han X, Ding H, Jiang Y, Zhang X, Yao C, Hong S, Zhang J, Shen Y, Hou G, Qu B, Zhou H, Qin Y, He Y, Ma J, Yin Z, Ye Z, Qian J, Jiang Q, Wu L, Guo Q, Chen S, Huang C, Kottyan LC, Weirauch MT, Vinuesa CG, Shen N. Dai D, et al. Among authors: ding h. Science. 2024 Jan 26;383(6681):413-421. doi: 10.1126/science.adf8531. Epub 2024 Jan 25. Science. 2024. PMID: 38271512
In this study, we screened for transcription factors driving ABC formation and found that zinc finger E-box binding homeobox 2 (ZEB2) is required for human and mouse ABC differentiation in vitro. ...In mice with toll-like receptor 7 (TLR7)-driven lupus, ZEB2 is essential f …
In this study, we screened for transcription factors driving ABC formation and found that zinc finger E-box binding homeobox 2 (ZEB2) …
Discovery of a potent SCAP degrader that ameliorates HFD-induced obesity, hyperlipidemia and insulin resistance via an autophagy-independent lysosomal pathway.
Zheng ZG, Zhu ST, Cheng HM, Zhang X, Cheng G, Thu PM, Wang SP, Li HJ, Ding M, Qiang L, Chen XW, Zhong Q, Li P, Xu X. Zheng ZG, et al. Among authors: ding m. Autophagy. 2021 Jul;17(7):1592-1613. doi: 10.1080/15548627.2020.1757955. Epub 2020 May 20. Autophagy. 2021. PMID: 32432943 Free PMC article.
SCAP (SREBF chaperone) regulates SREBFs (sterol regulatory element binding transcription factors) processing and stability, and, thus, becomes an emerging drug target to treat dyslipidemia and fatty liver disease. ...In this study, we identified a small molecule, lycorine, …
SCAP (SREBF chaperone) regulates SREBFs (sterol regulatory element binding transcription factors) processing and stability, and, thus …
SPOP mutations promote p62/SQSTM1-dependent autophagy and Nrf2 activation in prostate cancer.
Shi Q, Jin X, Zhang P, Li Q, Lv Z, Ding Y, He H, Wang Y, He Y, Zhao X, Zhao SM, Li Y, Gao K, Wang C. Shi Q, et al. Among authors: ding y. Cell Death Differ. 2022 Jun;29(6):1228-1239. doi: 10.1038/s41418-021-00913-w. Epub 2022 Jan 6. Cell Death Differ. 2022. PMID: 34987184 Free PMC article.
Functional disorders of p62 are closely associated with multiple neurodegenerative diseases and cancers. The gene encoding the E3 ubiquitin ligase substrate-binding adapter SPOP is frequently mutated in prostate cancer (PCa), but the molecular mechanisms underlying how SPO …
Functional disorders of p62 are closely associated with multiple neurodegenerative diseases and cancers. The gene encoding the E3 ubiquitin …
PCSK9 (Proprotein Convertase Subtilisin/Kexin 9) Enhances Platelet Activation, Thrombosis, and Myocardial Infarct Expansion by Binding to Platelet CD36.
Qi Z, Hu L, Zhang J, Yang W, Liu X, Jia D, Yao Z, Chang L, Pan G, Zhong H, Luo X, Yao K, Sun A, Qian J, Ding Z, Ge J. Qi Z, et al. Among authors: ding z. Circulation. 2021 Jan 5;143(1):45-61. doi: 10.1161/CIRCULATIONAHA.120.046290. Epub 2020 Sep 29. Circulation. 2021. PMID: 32988222
In line, PCSK9 enhances in vivo thrombosis in a FeCl(3)-injured mesenteric arteriole thrombosis mouse model, whereas PCSK9 inhibitor evolocumab ameliorates its enhancing effects. Mechanism studies revealed that PCSK9 binds to platelet CD36 and thus activates Src kinase and …
In line, PCSK9 enhances in vivo thrombosis in a FeCl(3)-injured mesenteric arteriole thrombosis mouse model, whereas PCSK9 inhibitor evolocu …
Directly targeting ASC by lonidamine alleviates inflammasome-driven diseases.
Chen C, Zhou Y, Ning X, Li S, Xue D, Wei C, Zhu Z, Sheng L, Lu B, Li Y, Ye X, Fu Y, Bai C, Cai W, Ding Y, Lin S, Yan G, Huang Y, Yin W. Chen C, et al. Among authors: ding y. J Neuroinflammation. 2022 Dec 28;19(1):315. doi: 10.1186/s12974-022-02682-w. J Neuroinflammation. 2022. PMID: 36577999 Free PMC article.
The inhibition of inflammasome activation and ASC oligomerization by LND was evaluated using western blot (WB), immunofluorescence (IF), quantitative polymerase chain reaction (qPCR) and enzyme-linked immunosorbent assay (ELISA) in murine bone marrow-derived macrophages (BMDMs). …
The inhibition of inflammasome activation and ASC oligomerization by LND was evaluated using western blot (WB), immunofluorescence (IF), qua …
Recognition and maturation of IL-18 by caspase-4 noncanonical inflammasome.
Shi X, Sun Q, Hou Y, Zeng H, Cao Y, Dong M, Ding J, Shao F. Shi X, et al. Among authors: ding j. Nature. 2023 Dec;624(7991):442-450. doi: 10.1038/s41586-023-06742-w. Epub 2023 Nov 22. Nature. 2023. PMID: 37993714
The crystal structure of the caspase-4-pro-IL-18 complex reveals a two-site (binary) substrate-recognition mechanism; the catalytic pocket engages the tetrapeptide, and a unique exosite that critically recognizes GSDMD(10) similarly binds to a specific structure formed joi …
The crystal structure of the caspase-4-pro-IL-18 complex reveals a two-site (binary) substrate-recognition mechanism; the catalytic pocket e …
A DNA nanorobot functions as a cancer therapeutic in response to a molecular trigger in vivo.
Li S, Jiang Q, Liu S, Zhang Y, Tian Y, Song C, Wang J, Zou Y, Anderson GJ, Han JY, Chang Y, Liu Y, Zhang C, Chen L, Zhou G, Nie G, Yan H, Ding B, Zhao Y. Li S, et al. Among authors: ding b. Nat Biotechnol. 2018 Mar;36(3):258-264. doi: 10.1038/nbt.4071. Epub 2018 Feb 12. Nat Biotechnol. 2018. PMID: 29431737
Our nanorobot is functionalized on the outside with a DNA aptamer that binds nucleolin, a protein specifically expressed on tumor-associated endothelial cells, and the blood coagulation protease thrombin within its inner cavity. ...
Our nanorobot is functionalized on the outside with a DNA aptamer that binds nucleolin, a protein specifically expressed on tumor-ass …
SPOP mutations promote tumor immune escape in endometrial cancer via the IRF1-PD-L1 axis.
Gao K, Shi Q, Gu Y, Yang W, He Y, Lv Z, Ding Y, Cao W, Wang C, Wan X. Gao K, et al. Among authors: ding y. Cell Death Differ. 2023 Feb;30(2):475-487. doi: 10.1038/s41418-022-01097-7. Epub 2022 Dec 8. Cell Death Differ. 2023. PMID: 36481790 Free PMC article.
However, the specific genetic alterations that drive aberrant overexpression of PD-L1 in cancer cells remain poorly understood. The gene encoding the E3 ubiquitin ligase substrate-binding adaptor SPOP is frequently mutated in endometrial cancer (EC). Here, we report that S …
However, the specific genetic alterations that drive aberrant overexpression of PD-L1 in cancer cells remain poorly understood. The gene enc …
Schlafen-5 inhibits LINE-1 retrotransposition.
Ding J, Wang S, Liu Q, Duan Y, Cheng T, Ye Z, Cui Z, Zhang A, Liu Q, Zhang Z, Zhang N, Liu Q, An N, Zhao J, Yi D, Li Q, Wang J, Zhang Y, Ma L, Guo S, Wang J, Liang C, Zhou J, Cen S, Li X. Ding J, et al. iScience. 2023 Sep 19;26(10):107968. doi: 10.1016/j.isci.2023.107968. eCollection 2023 Oct 20. iScience. 2023. PMID: 37810251 Free PMC article.
The ability of SLFN5 to bind to LINE-1 RNA and the involvement of the helicase domain of SLFN5 in its inhibitory activity suggest a mechanism that SLFN5 binds to LINE-1 RNA followed by dissociation of ORF1p through its helicase activity, resulting in impaired RNP formation …
The ability of SLFN5 to bind to LINE-1 RNA and the involvement of the helicase domain of SLFN5 in its inhibitory activity suggest a mechanis …
9,697 results