Exercise-Induced Autophagy Ameliorates Motor Symptoms Progressivity in Parkinson's Disease Through Alpha-Synuclein Degradation: A Review

Hanna Goenawan; Shabrina Kiasati; Nova Sylviana; Imam Megantara; Ronny Lesmana

doi:10.2147/NDT.S401416

Exercise-Induced Autophagy Ameliorates Motor Symptoms Progressivity in Parkinson's Disease Through Alpha-Synuclein Degradation: A Review

Neuropsychiatr Dis Treat. 2023 May 25:19:1253-1262. doi: 10.2147/NDT.S401416. eCollection 2023.

Authors

Hanna Goenawan¹, Shabrina Kiasati², Nova Sylviana¹, Imam Megantara¹, Ronny Lesmana¹

Affiliations

¹ Department of Biomedical Sciences, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia.
² Undergraduate Program, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia.

Abstract

This study reviews the molecular mechanism of exercise-induced autophagy/mitophagy and its possible mechanism in delaying motor symptoms progressivity in Parkinson's disease (PD). Relevant articles obtained from PubMed and EBSCOhost were reviewed. After analyzing the articles, it was found that autophagy can be induced by exercise and can possibly be activated through the AMPK-ULK1 pathway. Mitophagy can also be induced by exercise and can possibly be activated through PINK1/Parkin pathway and AMPK-dependent pathway. Moreover, exercise-induced autophagy can decrease the accumulation of toxic α-synuclein aggregates in PD and therefore can delay motor symptoms progressivity.

Keywords: Parkinson’s disease; alpha-synuclein; autophagy; exercise.

Publication types

Review