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M2 isoform of pyruvate kinase rewires glucose metabolism during radiation therapy to promote an antioxidant response and glioblastoma radioresistance.
Bailleul J, Ruan Y, Abdulrahman L, Scott AJ, Yazal T, Sung D, Park K, Hoang H, Nathaniel J, Chu FI, Palomera D, Sehgal A, Tsang JE, Nathanson DA, Xu S, Park JO, Ten Hoeve J, Bhat K, Qi N, Kornblum HI, Schaue D, McBride WH, Lyssiotis CA, Wahl DR, Vlashi E. Bailleul J, et al. Among authors: tsang je. Neuro Oncol. 2023 Nov 2;25(11):1989-2000. doi: 10.1093/neuonc/noad103. Neuro Oncol. 2023. PMID: 37279645 Free PMC article.
Targeting deoxycytidine kinase improves symptoms in mouse models of multiple sclerosis.
Chen BY, Salas JR, Trias AO, Perez Rodriguez A, Tsang JE, Guemes M, Le TM, Galic Z, Shepard HM, Steinman L, Nathanson DA, Czernin J, Witte ON, Radu CG, Schultz KA, Clark PM. Chen BY, et al. Among authors: tsang je. Immunology. 2023 Jan;168(1):152-169. doi: 10.1111/imm.13569. Epub 2022 Sep 4. Immunology. 2023. PMID: 35986643 Free PMC article.
Cytoplasmic p53 couples oncogene-driven glucose metabolism to apoptosis and is a therapeutic target in glioblastoma.
Mai WX, Gosa L, Daniels VW, Ta L, Tsang JE, Higgins B, Gilmore WB, Bayley NA, Harati MD, Lee JT, Yong WH, Kornblum HI, Bensinger SJ, Mischel PS, Rao PN, Clark PM, Cloughesy TF, Letai A, Nathanson DA. Mai WX, et al. Among authors: tsang je. Nat Med. 2017 Nov;23(11):1342-1351. doi: 10.1038/nm.4418. Epub 2017 Oct 9. Nat Med. 2017. PMID: 29035366 Free PMC article.