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M2 isoform of pyruvate kinase rewires glucose metabolism during radiation therapy to promote an antioxidant response and glioblastoma radioresistance.
Neuro Oncol. 2023 Nov 2;25(11):1989-2000. doi: 10.1093/neuonc/noad103.
Neuro Oncol. 2023.
PMID: 37279645
Free PMC article.
18F-Labeled brain-penetrant EGFR tyrosine kinase inhibitors for PET imaging of glioblastoma.
Narayanam MK, Tsang JE, Xu S, Nathanson DA, Murphy JM.
Narayanam MK, et al. Among authors: tsang je.
Chem Sci. 2023 Nov 9;14(47):13825-13831. doi: 10.1039/d3sc04424f. eCollection 2023 Dec 6.
Chem Sci. 2023.
PMID: 38075671
Free PMC article.
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Development of a Potent Brain-Penetrant EGFR Tyrosine Kinase Inhibitor against Malignant Brain Tumors.
Tsang JE, Urner LM, Kim G, Chow K, Baufeld L, Faull K, Cloughesy TF, Clark PM, Jung ME, Nathanson DA.
Tsang JE, et al.
ACS Med Chem Lett. 2020 May 1;11(10):1799-1809. doi: 10.1021/acsmedchemlett.9b00599. eCollection 2020 Oct 8.
ACS Med Chem Lett. 2020.
PMID: 33062157
Free PMC article.
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Targeting deoxycytidine kinase improves symptoms in mouse models of multiple sclerosis.
Chen BY, Salas JR, Trias AO, Perez Rodriguez A, Tsang JE, Guemes M, Le TM, Galic Z, Shepard HM, Steinman L, Nathanson DA, Czernin J, Witte ON, Radu CG, Schultz KA, Clark PM.
Chen BY, et al. Among authors: tsang je.
Immunology. 2023 Jan;168(1):152-169. doi: 10.1111/imm.13569. Epub 2022 Sep 4.
Immunology. 2023.
PMID: 35986643
Free PMC article.
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Cytoplasmic p53 couples oncogene-driven glucose metabolism to apoptosis and is a therapeutic target in glioblastoma.
Mai WX, Gosa L, Daniels VW, Ta L, Tsang JE, Higgins B, Gilmore WB, Bayley NA, Harati MD, Lee JT, Yong WH, Kornblum HI, Bensinger SJ, Mischel PS, Rao PN, Clark PM, Cloughesy TF, Letai A, Nathanson DA.
Mai WX, et al. Among authors: tsang je.
Nat Med. 2017 Nov;23(11):1342-1351. doi: 10.1038/nm.4418. Epub 2017 Oct 9.
Nat Med. 2017.
PMID: 29035366
Free PMC article.
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Picosecond-resolved fluorescence studies of substrate and cofactor-binding domain mutants in a thermophilic alcohol dehydrogenase uncover an extended network of communication.
Meadows CW, Tsang JE, Klinman JP.
Meadows CW, et al. Among authors: tsang je.
J Am Chem Soc. 2014 Oct 22;136(42):14821-33. doi: 10.1021/ja506667k. Epub 2014 Oct 14.
J Am Chem Soc. 2014.
PMID: 25314615
Free PMC article.
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