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O-GlcNAcylation enhances CPS1 catalytic efficiency for ammonia and promotes ureagenesis.
Soria LR, Makris G, D'Alessio AM, De Angelis A, Boffa I, Pravata VM, Rüfenacht V, Attanasio S, Nusco E, Arena P, Ferenbach AT, Paris D, Cuomo P, Motta A, Nitzahn M, Lipshutz GS, Martínez-Pizarro A, Richard E, Desviat LR, Häberle J, van Aalten DMF, Brunetti-Pierri N. Soria LR, et al. Among authors: pravata vm. Nat Commun. 2022 Sep 5;13(1):5212. doi: 10.1038/s41467-022-32904-x. Nat Commun. 2022. PMID: 36064721 Free PMC article.
The citron homology domain as a scaffold for Rho1 signaling.
Bartual SG, Wei W, Zhou Y, Pravata VM, Fang W, Yan K, Ferenbach AT, Lockhart DEA, van Aalten DMF. Bartual SG, et al. Among authors: pravata vm. Proc Natl Acad Sci U S A. 2021 Sep 28;118(39):e2110298118. doi: 10.1073/pnas.2110298118. Proc Natl Acad Sci U S A. 2021. PMID: 34544876 Free PMC article.
Catalytic deficiency of O-GlcNAc transferase leads to X-linked intellectual disability.
Pravata VM, Muha V, Gundogdu M, Ferenbach AT, Kakade PS, Vandadi V, Wilmes AC, Borodkin VS, Joss S, Stavridis MP, van Aalten DMF. Pravata VM, et al. Proc Natl Acad Sci U S A. 2019 Jul 23;116(30):14961-14970. doi: 10.1073/pnas.1900065116. Epub 2019 Jul 11. Proc Natl Acad Sci U S A. 2019. PMID: 31296563 Free PMC article.