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Excess filaggrin in keratinocytes is removed by extracellular vesicles to prevent premature death and this mechanism can be hijacked by Staphylococcus aureus in a TLR2-dependent fashion.
J Extracell Vesicles. 2023 Jun;12(6):e12335. doi: 10.1002/jev2.12335.
J Extracell Vesicles. 2023.
PMID: 37338870
Free PMC article.
Exposure of Keratinocytes to Candida Albicans in the Context of Atopic Milieu Induces Changes in the Surface Glycosylation Pattern of Small Extracellular Vesicles to Enhance Their Propensity to Interact With Inhibitory Siglec Receptors.
Kobiela A, Frackowiak JE, Biernacka A, Hovhannisyan L, Bogucka AE, Panek K, Paul AA, Lukomska J, Wang X, Giannoulatou E, Krolicka A, Zielinski J, Deptula M, Pikula M, Gabrielsson S, Ogg GS, Gutowska-Owsiak D.
Kobiela A, et al.
Front Immunol. 2022 Jun 9;13:884530. doi: 10.3389/fimmu.2022.884530. eCollection 2022.
Front Immunol. 2022.
PMID: 35784319
Free PMC article.
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Keratinocyte-derived small extracellular vesicles supply antigens for CD1a-resticted T cells and promote their type 2 bias in the context of filaggrin insufficiency.
Kobiela A, Hewelt-Belka W, Frąckowiak JE, Kordulewska N, Hovhannisyan L, Bogucka A, Etherington R, Piróg A, Dapic I, Gabrielsson S, Brown SJ, Ogg GS, Gutowska-Owsiak D.
Kobiela A, et al.
Front Immunol. 2024 Mar 22;15:1369238. doi: 10.3389/fimmu.2024.1369238. eCollection 2024.
Front Immunol. 2024.
PMID: 38585273
Free PMC article.
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In silico analysis of the profilaggrin sequence indicates alterations in the stability, degradation route, and intracellular protein fate in filaggrin null mutation carriers.
Paul AA, Szulc NA, Kobiela A, Brown SJ, Pokrzywa W, Gutowska-Owsiak D.
Paul AA, et al. Among authors: kobiela a.
Front Mol Biosci. 2023 May 2;10:1105678. doi: 10.3389/fmolb.2023.1105678. eCollection 2023.
Front Mol Biosci. 2023.
PMID: 37200867
Free PMC article.
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