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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2002 2
2003 2
2004 1
2005 1
2006 5
2007 7
2008 6
2009 4
2010 3
2011 5
2012 5
2013 4
2014 7
2015 8
2016 5
2017 8
2018 7
2019 7
2020 9
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2022 5
2023 7
2024 2

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108 results

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Page 1
Evolutionary classification of CRISPR-Cas systems: a burst of class 2 and derived variants.
Makarova KS, Wolf YI, Iranzo J, Shmakov SA, Alkhnbashi OS, Brouns SJJ, Charpentier E, Cheng D, Haft DH, Horvath P, Moineau S, Mojica FJM, Scott D, Shah SA, Siksnys V, Terns MP, Venclovas Č, White MF, Yakunin AF, Yan W, Zhang F, Garrett RA, Backofen R, van der Oost J, Barrangou R, Koonin EV. Makarova KS, et al. Among authors: siksnys v. Nat Rev Microbiol. 2020 Feb;18(2):67-83. doi: 10.1038/s41579-019-0299-x. Epub 2019 Dec 19. Nat Rev Microbiol. 2020. PMID: 31857715 Free PMC article. Review.
An AsCas12f-based compact genome-editing tool derived by deep mutational scanning and structural analysis.
Hino T, Omura SN, Nakagawa R, Togashi T, Takeda SN, Hiramoto T, Tasaka S, Hirano H, Tokuyama T, Uosaki H, Ishiguro S, Kagieva M, Yamano H, Ozaki Y, Motooka D, Mori H, Kirita Y, Kise Y, Itoh Y, Matoba S, Aburatani H, Yachie N, Karvelis T, Siksnys V, Ohmori T, Hoshino A, Nureki O. Hino T, et al. Among authors: siksnys v. Cell. 2023 Oct 26;186(22):4920-4935.e23. doi: 10.1016/j.cell.2023.08.031. Epub 2023 Sep 29. Cell. 2023. PMID: 37776859 Free article.
Transposon-associated TnpB is a programmable RNA-guided DNA endonuclease.
Karvelis T, Druteika G, Bigelyte G, Budre K, Zedaveinyte R, Silanskas A, Kazlauskas D, Venclovas Č, Siksnys V. Karvelis T, et al. Among authors: siksnys v. Nature. 2021 Nov;599(7886):692-696. doi: 10.1038/s41586-021-04058-1. Epub 2021 Oct 7. Nature. 2021. PMID: 34619744 Free PMC article.
TnpB structure reveals minimal functional core of Cas12 nuclease family.
Sasnauskas G, Tamulaitiene G, Druteika G, Carabias A, Silanskas A, Kazlauskas D, Venclovas Č, Montoya G, Karvelis T, Siksnys V. Sasnauskas G, et al. Among authors: siksnys v. Nature. 2023 Apr;616(7956):384-389. doi: 10.1038/s41586-023-05826-x. Epub 2023 Apr 5. Nature. 2023. PMID: 37020015
CRISPR adaptation from a structural perspective.
Sasnauskas G, Siksnys V. Sasnauskas G, et al. Among authors: siksnys v. Curr Opin Struct Biol. 2020 Dec;65:17-25. doi: 10.1016/j.sbi.2020.05.015. Epub 2020 Jun 20. Curr Opin Struct Biol. 2020. PMID: 32570107 Review.
Short prokaryotic Argonautes provide defence against incoming mobile genetic elements through NAD+ depletion.
Zaremba M, Dakineviciene D, Golovinas E, Zagorskaitė E, Stankunas E, Lopatina A, Sorek R, Manakova E, Ruksenaite A, Silanskas A, Asmontas S, Grybauskas A, Tylenyte U, Jurgelaitis E, Grigaitis R, Timinskas K, Venclovas Č, Siksnys V. Zaremba M, et al. Among authors: siksnys v. Nat Microbiol. 2022 Nov;7(11):1857-1869. doi: 10.1038/s41564-022-01239-0. Epub 2022 Oct 3. Nat Microbiol. 2022. PMID: 36192537
108 results