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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1959 1
1965 1
1966 2
1967 1
1969 1
1971 1
1972 1
1973 3
1974 6
1975 84
1976 62
1977 82
1978 80
1979 86
1980 129
1981 132
1982 146
1983 161
1984 169
1985 166
1986 214
1987 246
1988 281
1989 323
1990 384
1991 422
1992 584
1993 648
1994 756
1995 878
1996 939
1997 1061
1998 1221
1999 1352
2000 1547
2001 1806
2002 2053
2003 2610
2004 3268
2005 3842
2006 4180
2007 4979
2008 5694
2009 6642
2010 8311
2011 9982
2012 11649
2013 13782
2014 15096
2015 15921
2016 10410
2017 7760
2018 11357
2019 12943
2020 15177
2021 17255
2022 18423
2023 16150
2024 4264

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209,696 results

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Page 1
Lineage tracking reveals dynamic relationships of T cells in colorectal cancer.
Zhang L, Yu X, Zheng L, Zhang Y, Li Y, Fang Q, Gao R, Kang B, Zhang Q, Huang JY, Konno H, Guo X, Ye Y, Gao S, Wang S, Hu X, Ren X, Shen Z, Ouyang W, Zhang Z. Zhang L, et al. Among authors: huang jy. Nature. 2018 Dec;564(7735):268-272. doi: 10.1038/s41586-018-0694-x. Epub 2018 Oct 29. Nature. 2018. PMID: 30479382
T cells are key elements of cancer immunotherapy(1) but certain fundamental properties, such as the development and migration of T cells within tumours, remain unknown. ...Of the CD4(+) T cells, most tumour-infiltrating T regulatory (T(reg)) cel …
T cells are key elements of cancer immunotherapy(1) but certain fundamental properties, such as the development and migration of T …
Single-cell CRISPR screens in vivo map T cell fate regulomes in cancer.
Zhou P, Shi H, Huang H, Sun X, Yuan S, Chapman NM, Connelly JP, Lim SA, Saravia J, Kc A, Pruett-Miller SM, Chi H. Zhou P, et al. Among authors: huang h. Nature. 2023 Dec;624(7990):154-163. doi: 10.1038/s41586-023-06733-x. Epub 2023 Nov 15. Nature. 2023. PMID: 37968405 Free PMC article.
CD8(+) cytotoxic T cells (CTLs) orchestrate antitumour immunity and exhibit inherent heterogeneity(1,2), with precursor exhausted T (T(pex)) cells but not terminally exhausted T (T(ex)) cells capable of responding to existing immunotherapies(3-7 …
CD8(+) cytotoxic T cells (CTLs) orchestrate antitumour immunity and exhibit inherent heterogeneity(1,2), with precursor exhausted …
Stem cell-like memory T cells: The generation and application.
Wang Y, Qiu F, Xu Y, Hou X, Zhang Z, Huang L, Wang H, Xing H, Wu S. Wang Y, et al. Among authors: huang l. J Leukoc Biol. 2021 Dec;110(6):1209-1223. doi: 10.1002/JLB.5MR0321-145R. Epub 2021 Aug 17. J Leukoc Biol. 2021. PMID: 34402104 Review.
Stem cell-like memory T cells (Tscm), are a newly defined memory T cell subset with characteristics of long life span, consistent self-renewing, rapid differentiation into effector T cells, and apoptosis resistance. These features indicate that Tscm have grea …
Stem cell-like memory T cells (Tscm), are a newly defined memory T cell subset with characteristics of long life span, consist …
In vivo CRISPR screening reveals nutrient signaling processes underpinning CD8(+) T cell fate decisions.
Huang H, Zhou P, Wei J, Long L, Shi H, Dhungana Y, Chapman NM, Fu G, Saravia J, Raynor JL, Liu S, Palacios G, Wang YD, Qian C, Yu J, Chi H. Huang H, et al. Cell. 2021 Mar 4;184(5):1245-1261.e21. doi: 10.1016/j.cell.2021.02.021. Epub 2021 Feb 25. Cell. 2021. PMID: 33636132 Free PMC article.
How early events in effector T cell (T(EFF)) subsets tune memory T cell (T(MEM)) responses remains incompletely understood. Here, we systematically investigated metabolic factors in fate determination of T(EFF) and T(MEM) cells using in v …
How early events in effector T cell (T(EFF)) subsets tune memory T cell (T(MEM)) responses remains incompletely …
Tumor immunogenicity dictates reliance on TCF1 in CD8(+) T cells for response to immunotherapy.
Escobar G, Tooley K, Oliveras JP, Huang L, Cheng H, Bookstaver ML, Edwards C, Froimchuk E, Xue C, Mangani D, Krishnan RK, Hazel N, Rutigliani C, Jewell CM, Biasco L, Anderson AC. Escobar G, et al. Among authors: huang l. Cancer Cell. 2023 Sep 11;41(9):1662-1679.e7. doi: 10.1016/j.ccell.2023.08.001. Epub 2023 Aug 24. Cancer Cell. 2023. PMID: 37625402
Stem-like CD8(+) T cells are regulated by T cell factor 1 (TCF1) and are considered requisite for immune checkpoint blockade (ICB) response. However, recent findings indicate that reliance on TCF1(+)CD8(+) T cells for ICB efficacy may differ across tumor cont …
Stem-like CD8(+) T cells are regulated by T cell factor 1 (TCF1) and are considered requisite for immune checkpoint blockade ( …
Targeted therapy and immunotherapy for T cell acute lymphoblastic leukemia/lymphoma.
Huang YH, Wan CL, Dai HP, Xue SL. Huang YH, et al. Ann Hematol. 2023 Aug;102(8):2001-2013. doi: 10.1007/s00277-023-05286-3. Epub 2023 May 25. Ann Hematol. 2023. PMID: 37227492 Review.
T cell acute lymphoblastic leukemia/lymphoma (T-ALL/LBL) is an aggressive malignancy of progenitor T cells. Despite significant improvements in survival of T-ALL/LBL over the past decades, treatment of relapsed and refractory T-ALL (R/R T …
T cell acute lymphoblastic leukemia/lymphoma (T-ALL/LBL) is an aggressive malignancy of progenitor T cells. Despite sig …
Nano-optogenetic immunotherapy.
Huang K, Liu X, Han G, Zhou Y. Huang K, et al. Clin Transl Med. 2022 Sep;12(9):e1020. doi: 10.1002/ctm2.1020. Clin Transl Med. 2022. PMID: 36101937 Free PMC article.
CAR T-cell therapy takes advantage of genetically-modified T cells to express synthetic CAR molecules on the cell surface. ...In addition, hundreds of CAR-T products are currently under clinical trials to treat solid tumours. ...
CAR T-cell therapy takes advantage of genetically-modified T cells to express synthetic CAR molecules on the cell surface. ... …
SENP7 senses oxidative stress to sustain metabolic fitness and antitumor functions of CD8+ T cells.
Wu Z, Huang H, Han Q, Hu Z, Teng XL, Ding R, Ye Y, Yu X, Zhao R, Wang Z, Zou Q. Wu Z, et al. Among authors: huang h. J Clin Invest. 2022 Apr 1;132(7):e155224. doi: 10.1172/JCI155224. J Clin Invest. 2022. PMID: 35143421 Free PMC article.
The functional integrity of CD8+ T cells is tightly coupled to metabolic reprogramming, but how oxidative stress directs CD8+ T cell metabolic fitness in the tumor microenvironment (TME) remains elusive. ...Importantly, lowering T cell-intrinsic ROS restricte …
The functional integrity of CD8+ T cells is tightly coupled to metabolic reprogramming, but how oxidative stress directs CD8+ T …
Single-Cell Transcriptomic Analysis Reveals BCMA CAR-T Cell Dynamics in a Patient with Refractory Primary Plasma Cell Leukemia.
Li X, Guo X, Zhu Y, Wei G, Zhang Y, Li X, Xu H, Cui J, Wu W, He J, Ritchie ME, Weiskittel TM, Li H, Yu H, Ding L, Shao M, Luo Q, Xu X, Teng X, Chang AH, Zhang J, Huang H, Hu Y. Li X, et al. Among authors: huang h. Mol Ther. 2021 Feb 3;29(2):645-657. doi: 10.1016/j.ymthe.2020.11.028. Epub 2020 Dec 3. Mol Ther. 2021. PMID: 33278564 Free PMC article.
Here, we longitudinally profiled the transcriptomes of 55,488 T cells including CAR-T products, CAR-T cells, and endogenous T cells at the peak and remission phases in a plasma cell leukemia (PCL) patient treated with BCMA CAR-T cells by single- …
Here, we longitudinally profiled the transcriptomes of 55,488 T cells including CAR-T products, CAR-T cells, and endoge …
Influence of various medium environment to in vitro human T cell culture.
Xu H, Wang N, Cao W, Huang L, Zhou J, Sheng L. Xu H, et al. Among authors: huang l. In Vitro Cell Dev Biol Anim. 2018 Sep;54(8):559-566. doi: 10.1007/s11626-018-0273-3. Epub 2018 Jul 12. In Vitro Cell Dev Biol Anim. 2018. PMID: 30003447
Our study compared 6 commonly used cultural media for human T cells, including serum-containing media and serum-free media, namely RPMI 1640, IMDM, Gibco OpTmizer CTS T Cell Expansion SFM, Gibco AIM-V Medium CTS, LONZA X-VIVO 15, and StemSpan SFEM with or without Dy …
Our study compared 6 commonly used cultural media for human T cells, including serum-containing media and serum-free media, namely RP …
209,696 results
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