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Alternative UPS drug targets upstream the 26S proteasome.
Hjerpe R, Rodríguez MS. Hjerpe R, et al. Int J Biochem Cell Biol. 2008;40(6-7):1126-40. doi: 10.1016/j.biocel.2007.11.021. Epub 2007 Dec 8. Int J Biochem Cell Biol. 2008. PMID: 18203645 Review.
UBQLN2 Mediates Autophagy-Independent Protein Aggregate Clearance by the Proteasome.
Hjerpe R, Bett JS, Keuss MJ, Solovyova A, McWilliams TG, Johnson C, Sahu I, Varghese J, Wood N, Wightman M, Osborne G, Bates GP, Glickman MH, Trost M, Knebel A, Marchesi F, Kurz T. Hjerpe R, et al. Cell. 2016 Aug 11;166(4):935-949. doi: 10.1016/j.cell.2016.07.001. Epub 2016 Jul 28. Cell. 2016. PMID: 27477512 Free PMC article.
U1A is a positive regulator of the expression of heterologous and cellular genes involved in cell proliferation and migration.
Rovira E, Moreno B, Razquin N, Hjerpe R, Gonzalez-Lopez M, Barrio R, Ruiz de Los Mozos I, Ule J, Pastor F, Blazquez L, Fortes P. Rovira E, et al. Among authors: hjerpe r. Mol Ther Nucleic Acids. 2022 May 10;28:831-846. doi: 10.1016/j.omtn.2022.05.023. eCollection 2022 Jun 14. Mol Ther Nucleic Acids. 2022. PMID: 35664701 Free PMC article.
Tetramerization-defects of p53 result in aberrant ubiquitylation and transcriptional activity.
Lang V, Pallara C, Zabala A, Lobato-Gil S, Lopitz-Otsoa F, Farrás R, Hjerpe R, Torres-Ramos M, Zabaleta L, Blattner C, Hay RT, Barrio R, Carracedo A, Fernandez-Recio J, Rodríguez MS, Aillet F. Lang V, et al. Among authors: hjerpe r. Mol Oncol. 2014 Jul;8(5):1026-42. doi: 10.1016/j.molonc.2014.04.002. Epub 2014 Apr 13. Mol Oncol. 2014. PMID: 24816189 Free PMC article.
16 results