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Page 1
Targeting the Siglec-sialic acid axis promotes antitumor immune responses in preclinical models of glioblastoma.
Schmassmann P, Roux J, Buck A, Tatari N, Hogan S, Wang J, Rodrigues Mantuano N, Wieboldt R, Lee S, Snijder B, Kaymak D, Martins TA, Ritz MF, Shekarian T, McDaid M, Weller M, Weiss T, Läubli H, Hutter G. Schmassmann P, et al. Among authors: buck a. Sci Transl Med. 2023 Jul 19;15(705):eadf5302. doi: 10.1126/scitranslmed.adf5302. Epub 2023 Jul 19. Sci Transl Med. 2023. PMID: 37467314
Epigenetic neural glioblastoma enhances synaptic integration and predicts therapeutic vulnerability.
Drexler R, Khatri R, Sauvigny T, Mohme M, Maire CL, Ryba A, Zghaibeh Y, Dührsen L, Salviano-Silva A, Lamszus K, Westphal M, Gempt J, Wefers AK, Neumann J, Bode H, Hausmann F, Huber TB, Bonn S, Jütten K, Delev D, Weber KJ, Harter PN, Onken J, Vajkoczy P, Capper D, Wiestler B, Weller M, Snijder B, Buck A, Weiss T, Keough MB, Ni L, Monje M, Silverbush D, Hovestadt V, Suvà ML, Krishna S, Hervey-Jumper SL, Schüller U, Heiland DH, Hänzelmann S, Ricklefs FL. Drexler R, et al. Among authors: buck a. bioRxiv [Preprint]. 2023 Aug 7:2023.08.04.552017. doi: 10.1101/2023.08.04.552017. bioRxiv. 2023. PMID: 37609137 Free PMC article. Preprint.
Affinity fine-tuning anti-CAIX CAR-T cells mitigate on-target off-tumor side effects.
Wang Y, Buck A, Piel B, Zerefa L, Murugan N, Coherd CD, Miklosi AG, Johal H, Bastos RN, Huang K, Ficial M, Laimon YN, Signoretti S, Zhong Z, Hoang SM, Kastrunes GM, Grimaud M, Fayed A, Yuan HC, Nguyen QD, Thai T, Ivanova EV, Paweletz CP, Wu MR, Choueiri TK, Wee JO, Freeman GJ, Barbie DA, Marasco WA. Wang Y, et al. Among authors: buck a. Mol Cancer. 2024 Mar 16;23(1):56. doi: 10.1186/s12943-024-01952-w. Mol Cancer. 2024. PMID: 38491381 Free PMC article.
A prognostic neural epigenetic signature in high-grade glioma.
Drexler R, Khatri R, Sauvigny T, Mohme M, Maire CL, Ryba A, Zghaibeh Y, Dührsen L, Salviano-Silva A, Lamszus K, Westphal M, Gempt J, Wefers AK, Neumann JE, Bode H, Hausmann F, Huber TB, Bonn S, Jütten K, Delev D, Weber KJ, Harter PN, Onken J, Vajkoczy P, Capper D, Wiestler B, Weller M, Snijder B, Buck A, Weiss T, Göller PC, Sahm F, Menstel JA, Zimmer DN, Keough MB, Ni L, Monje M, Silverbush D, Hovestadt V, Suvà ML, Krishna S, Hervey-Jumper SL, Schüller U, Heiland DH, Hänzelmann S, Ricklefs FL. Drexler R, et al. Among authors: buck a. Nat Med. 2024 May 17. doi: 10.1038/s41591-024-02969-w. Online ahead of print. Nat Med. 2024. PMID: 38760585
Immune-restoring CAR-T cells display antitumor activity and reverse immunosuppressive TME in a humanized ccRCC mouse model.
Wang Y, Cho JW, Kastrunes G, Buck A, Razimbaud C, Culhane AC, Sun J, Braun DA, Choueiri TK, Wu CJ, Jones K, Nguyen QD, Zhu Z, Wei K, Zhu Q, Signoretti S, Freeman GJ, Hemberg M, Marasco WA. Wang Y, et al. Among authors: buck a. iScience. 2024 Jan 15;27(2):108879. doi: 10.1016/j.isci.2024.108879. eCollection 2024 Feb 16. iScience. 2024. PMID: 38327771 Free PMC article.
Anti-CAIX BBζ CAR4/8 T cells exhibit superior efficacy in a ccRCC mouse model.
Wang Y, Buck A, Grimaud M, Culhane AC, Kodangattil S, Razimbaud C, Bonal DM, Nguyen QD, Zhu Z, Wei K, O'Donnell ML, Huang Y, Signoretti S, Choueiri TK, Freeman GJ, Zhu Q, Marasco WA. Wang Y, et al. Among authors: buck a. Mol Ther Oncolytics. 2021 Dec 31;24:385-399. doi: 10.1016/j.omto.2021.12.019. eCollection 2022 Mar 17. Mol Ther Oncolytics. 2021. PMID: 35118195 Free PMC article.
Sensitivity towards the GRP78 inhibitor KP1339/IT-139 is characterized by apoptosis induction via caspase 8 upon disruption of ER homeostasis.
Schoenhacker-Alte B, Mohr T, Pirker C, Kryeziu K, Kuhn PS, Buck A, Hofmann T, Gerner C, Hermann G, Koellensperger G, Keppler BK, Berger W, Heffeter P. Schoenhacker-Alte B, et al. Among authors: buck a. Cancer Lett. 2017 Sep 28;404:79-88. doi: 10.1016/j.canlet.2017.07.009. Epub 2017 Jul 14. Cancer Lett. 2017. PMID: 28716523