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Year Number of Results
2007 1
2008 2
2009 3
2010 1
2012 1
2013 2
2014 1
2017 1
2021 4
2022 1
2023 2
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17 results

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Page 1
GDF15 promotes weight loss by enhancing energy expenditure in muscle.
Wang D, Townsend LK, DesOrmeaux GJ, Frangos SM, Batchuluun B, Dumont L, Kuhre RE, Ahmadi E, Hu S, Rebalka IA, Gautam J, Jabile MJT, Pileggi CA, Rehal S, Desjardins EM, Tsakiridis EE, Lally JSV, Juracic ES, Tupling AR, Gerstein HC, Paré G, Tsakiridis T, Harper ME, Hawke TJ, Speakman JR, Blondin DP, Holloway GP, Jørgensen SB, Steinberg GR. Wang D, et al. Among authors: jorgensen sb. Nature. 2023 Jul;619(7968):143-150. doi: 10.1038/s41586-023-06249-4. Epub 2023 Jun 28. Nature. 2023. PMID: 37380764 Free PMC article.
GDF15 increases insulin action in the liver and adipose tissue via a β-adrenergic receptor-mediated mechanism.
Sjøberg KA, Sigvardsen CM, Alvarado-Diaz A, Andersen NR, Larance M, Seeley RJ, Schjerling P, Knudsen JG, Katzilieris-Petras G, Clemmensen C, Jørgensen SB, De Bock K, Richter EA. Sjøberg KA, et al. Among authors: jorgensen sb. Cell Metab. 2023 Aug 8;35(8):1327-1340.e5. doi: 10.1016/j.cmet.2023.06.016. Epub 2023 Jul 19. Cell Metab. 2023. PMID: 37473755
GFRAL is the receptor for GDF15 and is required for the anti-obesity effects of the ligand.
Yang L, Chang CC, Sun Z, Madsen D, Zhu H, Padkjær SB, Wu X, Huang T, Hultman K, Paulsen SJ, Wang J, Bugge A, Frantzen JB, Nørgaard P, Jeppesen JF, Yang Z, Secher A, Chen H, Li X, John LM, Shan B, He Z, Gao X, Su J, Hansen KT, Yang W, Jørgensen SB. Yang L, et al. Among authors: jorgensen sb. Nat Med. 2017 Oct;23(10):1158-1166. doi: 10.1038/nm.4394. Epub 2017 Aug 28. Nat Med. 2017. PMID: 28846099
GFRAL-expressing neurons suppress food intake via aversive pathways.
Sabatini PV, Frikke-Schmidt H, Arthurs J, Gordian D, Patel A, Rupp AC, Adams JM, Wang J, Beck Jørgensen S, Olson DP, Palmiter RD, Myers MG Jr, Seeley RJ. Sabatini PV, et al. Among authors: beck jorgensen s. Proc Natl Acad Sci U S A. 2021 Feb 23;118(8):e2021357118. doi: 10.1073/pnas.2021357118. Proc Natl Acad Sci U S A. 2021. PMID: 33593916 Free PMC article.
Activation of the hypothalamic-pituitary-adrenal axis by exogenous and endogenous GDF15.
Cimino I, Kim H, Tung YCL, Pedersen K, Rimmington D, Tadross JA, Kohnke SN, Neves-Costa A, Barros A, Joaquim S, Bennett D, Melvin A, Lockhart SM, Rostron AJ, Scott J, Liu H, Burling K, Barker P, Clatworthy MR, Lee EC, Simpson AJ, Yeo GSH, Moita LF, Bence KK, Jørgensen SB, Coll AP, Breen DM, O'Rahilly S. Cimino I, et al. Among authors: jorgensen sb. Proc Natl Acad Sci U S A. 2021 Jul 6;118(27):e2106868118. doi: 10.1073/pnas.2106868118. Proc Natl Acad Sci U S A. 2021. PMID: 34187898 Free PMC article.
Plasma GDF15 levels are similar between subjects after bariatric surgery and matched controls and are unaffected by meals.
Martinussen C, Svane MS, Bojsen-Møller KN, Jensen CZ, Kristiansen VB, Bookout AL, Jørgensen SB, Holst JJ, Wewer Albrechtsen NJ, Madsbad S, Kuhre RE. Martinussen C, et al. Among authors: jorgensen sb. Am J Physiol Endocrinol Metab. 2021 Oct 1;321(4):E443-E452. doi: 10.1152/ajpendo.00190.2021. Epub 2021 Aug 9. Am J Physiol Endocrinol Metab. 2021. PMID: 34370594 Free article.
17 results