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Page 1
Efficient high-precision homology-directed repair-dependent genome editing by HDRobust.
Nat Methods. 2023 Sep;20(9):1388-1399. doi: 10.1038/s41592-023-01949-1. Epub 2023 Jul 20.
Nat Methods. 2023.
PMID: 37474806
Free PMC article.
Improved gRNA secondary structures allow editing of target sites resistant to CRISPR-Cas9 cleavage.
Riesenberg S, Helmbrecht N, Kanis P, Maricic T, Pääbo S.
Riesenberg S, et al. Among authors: helmbrecht n.
Nat Commun. 2022 Jan 25;13(1):489. doi: 10.1038/s41467-022-28137-7.
Nat Commun. 2022.
PMID: 35078986
Free PMC article.
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Detection of unintended on-target effects in CRISPR genome editing by DNA donors carrying diagnostic substitutions.
Lackner M, Helmbrecht N, Pääbo S, Riesenberg S.
Lackner M, et al. Among authors: helmbrecht n.
Nucleic Acids Res. 2023 Mar 21;51(5):e26. doi: 10.1093/nar/gkac1254.
Nucleic Acids Res. 2023.
PMID: 36620901
Free PMC article.
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The modern human aryl hydrocarbon receptor is more active when ancestralized by genome editing.
Helmbrecht N, Lackner M, Maricic T, Pääbo S.
Helmbrecht N, et al.
Proc Natl Acad Sci U S A. 2024 May 28;121(22):e2402159121. doi: 10.1073/pnas.2402159121. Epub 2024 May 13.
Proc Natl Acad Sci U S A. 2024.
PMID: 38739836
Free PMC article.
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Comment on "Reintroduction of the archaic variant of NOVA1 in cortical organoids alters neurodevelopment".
Maricic T, Helmbrecht N, Riesenberg S, Macak D, Kanis P, Lackner M, Pugach-Matveeva AD, Pääbo S.
Maricic T, et al. Among authors: helmbrecht n.
Science. 2021 Oct 15;374(6565):eabi6060. doi: 10.1126/science.abi6060. Epub 2021 Oct 14.
Science. 2021.
PMID: 34648345
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