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Discovery of senolytics using machine learning.
Smer-Barreto V, Quintanilla A, Elliott RJR, Dawson JC, Sun J, Campa VM, Lorente-Macías Á, Unciti-Broceta A, Carragher NO, Acosta JC, Oyarzún DA. Smer-Barreto V, et al. Among authors: elliott rjr. Nat Commun. 2023 Jun 10;14(1):3445. doi: 10.1038/s41467-023-39120-1. Nat Commun. 2023. PMID: 37301862 Free PMC article.
Multiparametric High-Content Cell Painting Identifies Copper Ionophores as Selective Modulators of Esophageal Cancer Phenotypes.
Hughes RE, Elliott RJR, Li X, Munro AF, Makda A, Carter RN, Morton NM, Fujihara K, Clemons NJ, Fitzgerald R, O'Neill JR, Hupp T, Carragher NO. Hughes RE, et al. Among authors: elliott rjr. ACS Chem Biol. 2022 Jul 15;17(7):1876-1889. doi: 10.1021/acschembio.2c00301. Epub 2022 Jun 13. ACS Chem Biol. 2022. PMID: 35696676 Free PMC article.
High-Content Phenotypic Profiling in Esophageal Adenocarcinoma Identifies Selectively Active Pharmacological Classes of Drugs for Repurposing and Chemical Starting Points for Novel Drug Discovery.
Hughes RE, Elliott RJR, Munro AF, Makda A, O'Neill JR, Hupp T, Carragher NO. Hughes RE, et al. Among authors: elliott rjr. SLAS Discov. 2020 Aug;25(7):770-782. doi: 10.1177/2472555220917115. Epub 2020 May 22. SLAS Discov. 2020. PMID: 32441181 Free PMC article.