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Acetyl-CoA biosynthesis drives resistance to histone acetyltransferase inhibition.
Bishop TR, Subramanian C, Bilotta EM, Garnar-Wortzel L, Ramos AR, Zhang Y, Asiaban JN, Ott CJ, Rock CO, Erb MA. Bishop TR, et al. Among authors: ramos ar. Nat Chem Biol. 2023 Oct;19(10):1215-1222. doi: 10.1038/s41589-023-01320-7. Epub 2023 May 1. Nat Chem Biol. 2023. PMID: 37127754 Free PMC article.
Collateral lethality between HDAC1 and HDAC2 exploits cancer-specific NuRD complex vulnerabilities.
Zhang Y, Remillard D, Onubogu U, Karakyriakou B, Asiaban JN, Ramos AR, Bowland K, Bishop TR, Barta PA, Nance S, Durbin AD, Ott CJ, Janiszewska M, Cravatt BF, Erb MA. Zhang Y, et al. Among authors: ramos ar. Nat Struct Mol Biol. 2023 Aug;30(8):1160-1171. doi: 10.1038/s41594-023-01041-4. Epub 2023 Jul 24. Nat Struct Mol Biol. 2023. PMID: 37488358 Free PMC article.
Chemical Inhibition of ENL/AF9 YEATS Domains in Acute Leukemia.
Garnar-Wortzel L, Bishop TR, Kitamura S, Milosevich N, Asiaban JN, Zhang X, Zheng Q, Chen E, Ramos AR, Ackerman CJ, Hampton EN, Chatterjee AK, Young TS, Hull MV, Sharpless KB, Cravatt BF, Wolan DW, Erb MA. Garnar-Wortzel L, et al. Among authors: ramos ar. ACS Cent Sci. 2021 May 26;7(5):815-830. doi: 10.1021/acscentsci.0c01550. Epub 2021 Apr 30. ACS Cent Sci. 2021. PMID: 34079898 Free PMC article.