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R-Ketorolac Targets Cdc42 and Rac1 and Alters Ovarian Cancer Cell Behaviors Critical for Invasion and Metastasis.
Guo Y, Kenney SR, Muller CY, Adams S, Rutledge T, Romero E, Murray-Krezan C, Prekeris R, Sklar LA, Hudson LG, Wandinger-Ness A. Guo Y, et al. Among authors: prekeris r. Mol Cancer Ther. 2015 Oct;14(10):2215-27. doi: 10.1158/1535-7163.MCT-15-0419. Epub 2015 Jul 23. Mol Cancer Ther. 2015. PMID: 26206334 Free PMC article.
In the present study, we establish R-ketorolac as an allosteric inhibitor of Cdc42 and Rac1. Cell-based assays validate R-ketorolac activity against Cdc42 and Rac1. ...Furthermore, GTPase inhibition by R-ketorolac reduces downstream p21-activated kinases (PAK …
In the present study, we establish R-ketorolac as an allosteric inhibitor of Cdc42 and Rac1. Cell-based assays validate R-keto …
VAMP-7 mediates vesicular transport from endosomes to lysosomes.
Advani RJ, Yang B, Prekeris R, Lee KC, Klumperman J, Scheller RH. Advani RJ, et al. Among authors: prekeris r. J Cell Biol. 1999 Aug 23;146(4):765-76. doi: 10.1083/jcb.146.4.765. J Cell Biol. 1999. PMID: 10459012 Free PMC article.
Identification of Rab11 as a small GTPase binding protein for the Evi5 oncogene.
Westlake CJ, Junutula JR, Simon GC, Pilli M, Prekeris R, Scheller RH, Jackson PK, Eldridge AG. Westlake CJ, et al. Among authors: prekeris r. Proc Natl Acad Sci U S A. 2007 Jan 23;104(4):1236-41. doi: 10.1073/pnas.0610500104. Epub 2007 Jan 17. Proc Natl Acad Sci U S A. 2007. PMID: 17229837 Free PMC article.