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Structural snapshots along K48-linked ubiquitin chain formation by the HECT E3 UBR5.
Hehl LA, Horn-Ghetko D, Prabu JR, Vollrath R, Vu DT, Pérez Berrocal DA, Mulder MPC, van der Heden van Noort GJ, Schulman BA. Hehl LA, et al. Among authors: vollrath r. Nat Chem Biol. 2024 Feb;20(2):190-200. doi: 10.1038/s41589-023-01414-2. Epub 2023 Aug 24. Nat Chem Biol. 2024. PMID: 37620400 Free PMC article.
Protein engineering of a ubiquitin-variant inhibitor of APC/C identifies a cryptic K48 ubiquitin chain binding site.
Watson ER, Grace CRR, Zhang W, Miller DJ, Davidson IF, Prabu JR, Yu S, Bolhuis DL, Kulko ET, Vollrath R, Haselbach D, Stark H, Peters JM, Brown NG, Sidhu SS, Schulman BA. Watson ER, et al. Among authors: vollrath r. Proc Natl Acad Sci U S A. 2019 Aug 27;116(35):17280-17289. doi: 10.1073/pnas.1902889116. Epub 2019 Jul 26. Proc Natl Acad Sci U S A. 2019. PMID: 31350353 Free PMC article.