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Page 1
Structure of the thrombopoietin-MPL receptor complex is a blueprint for biasing hematopoiesis.
Cell. 2023 Sep 14;186(19):4189-4203.e22. doi: 10.1016/j.cell.2023.07.037. Epub 2023 Aug 25.
Cell. 2023.
PMID: 37633268
Free article.
IL-2 is inactivated by the acidic pH environment of tumors enabling engineering of a pH-selective mutein.
Gaggero S, Martinez-Fabregas J, Cozzani A, Fyfe PK, Leprohon M, Yang J, Thomasen FE, Winkelmann H, Magnez R, Conti AG, Wilmes S, Pohler E, van Gijsel Bonnello M, Thuru X, Quesnel B, Soncin F, Piehler J, Lindorff-Larsen K, Roychoudhuri R, Moraga I, Mitra S.
Gaggero S, et al. Among authors: winkelmann h.
Sci Immunol. 2022 Dec 9;7(78):eade5686. doi: 10.1126/sciimmunol.ade5686. Epub 2022 Dec 2.
Sci Immunol. 2022.
PMID: 36459543
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Mechanism of homodimeric cytokine receptor activation and dysregulation by oncogenic mutations.
Wilmes S, Hafer M, Vuorio J, Tucker JA, Winkelmann H, Löchte S, Stanly TA, Pulgar Prieto KD, Poojari C, Sharma V, Richter CP, Kurre R, Hubbard SR, Garcia KC, Moraga I, Vattulainen I, Hitchcock IS, Piehler J.
Wilmes S, et al. Among authors: winkelmann h.
Science. 2020 Feb 7;367(6478):643-652. doi: 10.1126/science.aaw3242.
Science. 2020.
PMID: 32029621
Free PMC article.
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Calibration of cell-intrinsic interleukin-2 response thresholds guides design of a regulatory T cell biased agonist.
Glassman CR, Su L, Majri-Morrison SS, Winkelmann H, Mo F, Li P, Pérez-Cruz M, Ho PP, Koliesnik I, Nagy N, Hnizdilova T, Picton LK, Kovar M, Bollyky P, Steinman L, Meyer E, Piehler J, Leonard WJ, Garcia KC.
Glassman CR, et al. Among authors: winkelmann h.
Elife. 2021 May 18;10:e65777. doi: 10.7554/eLife.65777.
Elife. 2021.
PMID: 34003116
Free PMC article.
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Ligand-induced type II interleukin-4 receptor dimers are sustained by rapid re-association within plasma membrane microcompartments.
Richter D, Moraga I, Winkelmann H, Birkholz O, Wilmes S, Schulte M, Kraich M, Kenneweg H, Beutel O, Selenschik P, Paterok D, Gavutis M, Schmidt T, Garcia KC, Müller TD, Piehler J.
Richter D, et al. Among authors: winkelmann h.
Nat Commun. 2017 Jul 14;8:15976. doi: 10.1038/ncomms15976.
Nat Commun. 2017.
PMID: 28706306
Free PMC article.
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Instructive roles for cytokine-receptor binding parameters in determining signaling and functional potency.
Moraga I, Richter D, Wilmes S, Winkelmann H, Jude K, Thomas C, Suhoski MM, Engleman EG, Piehler J, Garcia KC.
Moraga I, et al. Among authors: winkelmann h.
Sci Signal. 2015 Nov 10;8(402):ra114. doi: 10.1126/scisignal.aab2677.
Sci Signal. 2015.
PMID: 26554818
Free PMC article.
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