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A TGFβ-ECM-integrin signaling axis drives structural reconfiguration of the bile duct to promote polycystic liver disease.
Waddell SH, Yao Y, Olaizola P, Walker A, Jarman EJ, Gournopanos K, Gradinaru A, Christodoulou E, Gautier P, Boerrigter MM, Cadamuro M, Fabris L, Drenth JP, Kendall TJ, Banales JM, Khamseh A, Mill P, Boulter L. Waddell SH, et al. Among authors: gradinaru a. Sci Transl Med. 2023 Sep 13;15(713):eabq5930. doi: 10.1126/scitranslmed.abq5930. Epub 2023 Sep 13. Sci Transl Med. 2023. PMID: 37703354 Free PMC article.
Van Gogh-like 2 is essential for the architectural patterning of the mammalian biliary tree.
Raab M, Christodoulou E, Krishnankutty R, Gradinaru A, Walker AD, Olaizola P, Younger NT, Lyons AM, Jarman EJ, Gournopanos K, von Kriegsheim A, Waddell SH, Boulter L. Raab M, et al. Among authors: gradinaru a. J Hepatol. 2024 Mar 7:S0168-8278(24)00149-1. doi: 10.1016/j.jhep.2024.02.030. Online ahead of print. J Hepatol. 2024. PMID: 38460794 Free article.