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Speg interactions that regulate the stability of excitation-contraction coupling protein complexes in triads and dyads.
Lee CS, Jung SY, Yee RSZ, Agha NH, Hong J, Chang T, Babcock LW, Fleischman JD, Clayton B, Hanna AD, Ward CS, Lanza D, Hurley AE, Zhang P, Wehrens XHT, Lagor WR, Rodney GG, Hamilton SL. Lee CS, et al. Among authors: hurley ae. Commun Biol. 2023 Sep 14;6(1):942. doi: 10.1038/s42003-023-05330-y. Commun Biol. 2023. PMID: 37709832 Free PMC article.
AAV-CRISPR Gene Editing Is Negated by Pre-existing Immunity to Cas9.
Li A, Tanner MR, Lee CM, Hurley AE, De Giorgi M, Jarrett KE, Davis TH, Doerfler AM, Bao G, Beeton C, Lagor WR. Li A, et al. Among authors: hurley ae. Mol Ther. 2020 Jun 3;28(6):1432-1441. doi: 10.1016/j.ymthe.2020.04.017. Epub 2020 Apr 19. Mol Ther. 2020. PMID: 32348718 Free PMC article.
Intestinal Deletion of 3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase Promotes Expansion of the Resident Stem Cell Compartment.
Doerfler AM, Han J, Jarrett KE, Tang L, Jain A, Saltzman A, De Giorgi M, Chuecos M, Hurley AE, Li A, Morand P, Ayala C, Goodlett DR, Malovannaya A, Martin JF, de Aguiar Vallim TQ, Shroyer N, Lagor WR. Doerfler AM, et al. Among authors: hurley ae. Arterioscler Thromb Vasc Biol. 2022 Apr;42(4):381-394. doi: 10.1161/ATVBAHA.122.317320. Epub 2022 Feb 17. Arterioscler Thromb Vasc Biol. 2022. PMID: 35172604 Free PMC article.
A Self-Deleting AAV-CRISPR System for In Vivo Genome Editing.
Li A, Lee CM, Hurley AE, Jarrett KE, De Giorgi M, Lu W, Balderrama KS, Doerfler AM, Deshmukh H, Ray A, Bao G, Lagor WR. Li A, et al. Among authors: hurley ae. Mol Ther Methods Clin Dev. 2018 Dec 6;12:111-122. doi: 10.1016/j.omtm.2018.11.009. eCollection 2019 Mar 15. Mol Ther Methods Clin Dev. 2018. PMID: 30619914 Free PMC article.
LPA disruption with AAV-CRISPR potently lowers plasma apo(a) in transgenic mouse model: A proof-of-concept study.
Doerfler AM, Park SH, Assini JM, Youssef A, Saxena L, Yaseen AB, De Giorgi M, Chuecos M, Hurley AE, Li A, Marcovina SM, Bao G, Boffa MB, Koschinsky ML, Lagor WR. Doerfler AM, et al. Among authors: hurley ae. Mol Ther Methods Clin Dev. 2022 Oct 13;27:337-351. doi: 10.1016/j.omtm.2022.10.009. eCollection 2022 Dec 8. Mol Ther Methods Clin Dev. 2022. PMID: 36381302 Free PMC article.
In vivo genome editing at the albumin locus to treat methylmalonic acidemia.
Schneller JL, Lee CM, Venturoni LE, Chandler RJ, Li A, Myung S, Cradick TJ, Hurley AE, Lagor WR, Bao G, Venditti CP. Schneller JL, et al. Among authors: hurley ae. Mol Ther Methods Clin Dev. 2021 Nov 11;23:619-632. doi: 10.1016/j.omtm.2021.11.004. eCollection 2021 Dec 10. Mol Ther Methods Clin Dev. 2021. PMID: 34901307 Free PMC article.
Highly conserved amino acid residues in apolipoprotein A1 discordantly induce high density lipoprotein assembly in vitro and in vivo.
Yelamanchili D, Liu J, Gotto AM Jr, Hurley AE, Lagor WR, Gillard BK, Davidson WS, Pownall HJ, Rosales C. Yelamanchili D, et al. Among authors: hurley ae. Biochim Biophys Acta Mol Cell Biol Lipids. 2020 Dec;1865(12):158794. doi: 10.1016/j.bbalip.2020.158794. Epub 2020 Aug 15. Biochim Biophys Acta Mol Cell Biol Lipids. 2020. PMID: 32810603