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Suppression of antitumor T cell immunity by the oncometabolite (R)-2-hydroxyglutarate.
Bunse L, Pusch S, Bunse T, Sahm F, Sanghvi K, Friedrich M, Alansary D, Sonner JK, Green E, Deumelandt K, Kilian M, Neftel C, Uhlig S, Kessler T, von Landenberg A, Berghoff AS, Marsh K, Steadman M, Zhu D, Nicolay B, Wiestler B, Breckwoldt MO, Al-Ali R, Karcher-Bausch S, Bozza M, Oezen I, Kramer M, Meyer J, Habel A, Eisel J, Poschet G, Weller M, Preusser M, Nadji-Ohl M, Thon N, Burger MC, Harter PN, Ratliff M, Harbottle R, Benner A, Schrimpf D, Okun J, Herold-Mende C, Turcan S, Kaulfuss S, Hess-Stumpp H, Bieback K, Cahill DP, Plate KH, Hänggi D, Dorsch M, Suvà ML, Niemeyer BA, von Deimling A, Wick W, Platten M. Bunse L, et al. Among authors: harbottle r. Nat Med. 2018 Aug;24(8):1192-1203. doi: 10.1038/s41591-018-0095-6. Epub 2018 Jul 9. Nat Med. 2018. PMID: 29988124
The oncometabolite (R)-2-hydroxyglutarate (R-2-HG) produced by isocitrate dehydrogenase (IDH) mutations promotes gliomagenesis via DNA and histone methylation. Here, we identify an additional activity of R-2-HG: tumor cell-derived R-2-HG is taken up by …
The oncometabolite (R)-2-hydroxyglutarate (R-2-HG) produced by isocitrate dehydrogenase (IDH) mutations promotes gliomagenesis …
NLGN4X TCR transgenic T cells to treat gliomas.
Krämer C, Kilian M, Chih YC, Kourtesakis A, Hoffmann DC, Boschert T, Koopmann P, Sanghvi K, De Roia A, Jung S, Jähne K, Day B, Shultz LD, Ratliff M, Harbottle R, Green EW, Will R, Wick W, Platten M, Bunse L. Krämer C, et al. Among authors: harbottle r. Neuro Oncol. 2024 Feb 2;26(2):266-278. doi: 10.1093/neuonc/noad172. Neuro Oncol. 2024. PMID: 37715782 Free PMC article.
An episomal DNA vector platform for the persistent genetic modification of pluripotent stem cells and their differentiated progeny.
Roig-Merino A, Urban M, Bozza M, Peterson JD, Bullen L, Büchler-Schäff M, Stäble S, van der Hoeven F, Müller-Decker K, McKay TR, Milsom MD, Harbottle RP. Roig-Merino A, et al. Among authors: harbottle rp. Stem Cell Reports. 2022 Jan 11;17(1):143-158. doi: 10.1016/j.stemcr.2021.11.011. Epub 2021 Dec 22. Stem Cell Reports. 2022. PMID: 34942088 Free PMC article.
Safe and stable generation of induced pluripotent stem cells using doggybone DNA vectors.
Thornton CD, Fielding S, Karbowniczek K, Roig-Merino A, Burrows AE, FitzPatrick LM, Sharaireh A, Tite JP, Mole SE, Harbottle RP, Caproni LJ, McKay TR. Thornton CD, et al. Among authors: harbottle rp. Mol Ther Methods Clin Dev. 2021 Oct 5;23:348-358. doi: 10.1016/j.omtm.2021.09.018. eCollection 2021 Dec 10. Mol Ther Methods Clin Dev. 2021. PMID: 34729381 Free PMC article.
Discontinuous dewetting dynamics of highly viscous droplets on chemically heterogeneous substrates.
Jiang J, Jackson F, Tangparitkul S, Wilson MCT, Harbottle D. Jiang J, et al. Among authors: harbottle d. J Colloid Interface Sci. 2023 Jan;629(Pt B):345-356. doi: 10.1016/j.jcis.2022.09.064. Epub 2022 Sep 15. J Colloid Interface Sci. 2023. PMID: 36162392 Free article.
The LBM simulation revealed that daughter droplets formed when teta(R) > 164, with the final droplet shape accurately described by imposing a diffuse wettability boundary condition....
The LBM simulation revealed that daughter droplets formed when teta(R) > 164, with the final droplet shape accurately described by …
Are plasma homocysteine and methionine elevated when binging and purging behavior complicates anorexia nervosa? Evidence against the transdiagnostic theory of eating disorders.
Innis SM, Birmingham CL, Harbottle EJ. Innis SM, et al. Among authors: harbottle ej. Eat Weight Disord. 2009 Dec;14(4):e184-9. doi: 10.1007/BF03325115. Eat Weight Disord. 2009. PMID: 20179404
OBJECTIVE: To determine whether plasma total homocysteine (tHcy) and plasma methionine levels are different in anorexia nervosa restricting type (AN-R) compared to anorexia nervosa binge eating/purging type (AN-BP). ...RESULTS: Samples were obtained from AN-R (N=30) …
OBJECTIVE: To determine whether plasma total homocysteine (tHcy) and plasma methionine levels are different in anorexia nervosa restricting …