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MYC multimers shield stalled replication forks from RNA polymerase.
Solvie D, Baluapuri A, Uhl L, Fleischhauer D, Endres T, Papadopoulos D, Aziba A, Gaballa A, Mikicic I, Isaakova E, Giansanti C, Jansen J, Jungblut M, Klein T, Schülein-Völk C, Maric H, Doose S, Sauer M, Beli P, Rosenwald A, Dobbelstein M, Wolf E, Eilers M. Solvie D, et al. Among authors: uhl l. Nature. 2022 Dec;612(7938):148-155. doi: 10.1038/s41586-022-05469-4. Epub 2022 Nov 23. Nature. 2022. PMID: 36424410
Endothelial Notch1 signaling in white adipose tissue promotes cancer cachexia.
Taylor J, Uhl L, Moll I, Hasan SS, Wiedmann L, Morgenstern J, Giaimo BD, Friedrich T, Alsina-Sanchis E, De Angelis Rigotti F, Mülfarth R, Kaltenbach S, Schenk D, Nickel F, Fleming T, Sprinzak D, Mogler C, Korff T, Billeter AT, Müller-Stich BP, Berriel Diaz M, Borggrefe T, Herzig S, Rohm M, Rodriguez-Vita J, Fischer A. Taylor J, et al. Among authors: uhl l. Nat Cancer. 2023 Nov;4(11):1544-1560. doi: 10.1038/s43018-023-00622-y. Epub 2023 Sep 25. Nat Cancer. 2023. PMID: 37749321 Free PMC article.
The MYCN oncoprotein is an RNA-binding accessory factor of the nuclear exosome targeting complex.
Papadopoulos D, Ha SA, Fleischhauer D, Uhl L, Russell TJ, Mikicic I, Schneider K, Brem A, Valanju OR, Cossa G, Gallant P, Schuelein-Voelk C, Maric HM, Beli P, Büchel G, Vos SM, Eilers M. Papadopoulos D, et al. Among authors: uhl l. Mol Cell. 2024 Jun 6;84(11):2070-2086.e20. doi: 10.1016/j.molcel.2024.04.007. Epub 2024 May 3. Mol Cell. 2024. PMID: 38703770 Free article.
Beyond gene expression: how MYC relieves transcription stress.
Papadopoulos D, Uhl L, Ha SA, Eilers M. Papadopoulos D, et al. Among authors: uhl l. Trends Cancer. 2023 Oct;9(10):805-816. doi: 10.1016/j.trecan.2023.06.008. Epub 2023 Jul 7. Trends Cancer. 2023. PMID: 37422352 Review.