Role of exosomes in prostate cancer and male fertility

Dwaipayan Dey; Srestha Ghosh; Divya Mirgh; Siva Parsad Panda; Niraj Kumar Jha; Saurabh Kumar Jha

doi:10.1016/j.drudis.2023.103791

Role of exosomes in prostate cancer and male fertility

Drug Discov Today. 2023 Nov;28(11):103791. doi: 10.1016/j.drudis.2023.103791. Epub 2023 Sep 28.

Authors

Dwaipayan Dey¹, Srestha Ghosh², Divya Mirgh³, Siva Parsad Panda⁴, Niraj Kumar Jha⁵, Saurabh Kumar Jha⁶

Affiliations

¹ Department of Microbiology, Ramakrishna Mission Vivekananda Centenary College, Rahara, West Bengal 700118, India.
² Department of Microbiology, Lady Brabourne College, Kolkata 700017, West Bengal, India.
³ Johns Hopkins University, Baltimore, MD 21218, USA.
⁴ Institute of Pharmaceutical Research, GLA University, Mathura, Uttar Pradesh 281406, India.
⁵ Department of Biotechnology, School of Engineering and Technology, Sharda University, Greater Noida 201310, India; School of Bioengineering & Biosciences, Lovely Professional University, Phagwara 144411, India; Department of Biotechnology Engineering and Food Technology, Chandigarh University, Mohali 140413, India. Electronic address: nirajkumarjha2011@gmail.com.
⁶ Department of Biotechnology, School of Engineering and Technology, Sharda University, Greater Noida 201310, India; Center for Global Health Research, Saveetha Medical College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, India; Department of Biotechnology, School of Applied and Life Sciences (SALS), Uttaranchal, University, Dehradun, India. Electronic address: saurabh.jha@sharda.ac.in.

PMID: 37777169
DOI: 10.1016/j.drudis.2023.103791

Abstract

Prostate cancer (PCa) is the second most common and fifth most aggressive neoplasm among men worldwide. In the last decade, extracellular vesicle (EV) research has decoded multiple unsolved cancer-related mysteries. EVs can be classified as microvesicles, apoptotic bodies, and exosomes, among others. Exosomes play a key role in cellular signaling. Their internal cargos (nucleic acids, proteins, lipids) influence the recipient cell. In PCa, the exosome is the regulator of cancer progression. It is also a promising theranostics tool for PCa. Moreover, exosomes have strong participation in male fertility complications. This review aims to highlight the exosome theranostics signature in PCa and its association with male fertility.

Keywords: exosomes; metastasis; prostate cancer; seminal exosomes; therapeutic.

Publication types

Review

MeSH terms

Cell-Derived Microparticles* / metabolism
Exosomes*
Extracellular Vesicles* / metabolism
Fertility
Humans
Male
Prostatic Neoplasms*