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Negative DNA supercoiling induces genome-wide Cas9 off-target activity.
Newton MD, Losito M, Smith QM, Parnandi N, Taylor BJ, Akcakaya P, Maresca M, van Eijk P, Reed SH, Boulton SJ, King GA, Cuomo ME, Rueda DS. Newton MD, et al. Among authors: losito m. Mol Cell. 2023 Oct 5;83(19):3533-3545.e5. doi: 10.1016/j.molcel.2023.09.008. Mol Cell. 2023. PMID: 37802026 Free article.
Cas12a target search and cleavage on force-stretched DNA.
Losito M, Smith QM, Newton MD, Cuomo ME, Rueda DS. Losito M, et al. Phys Chem Chem Phys. 2021 Dec 8;23(47):26640-26644. doi: 10.1039/d1cp03408a. Phys Chem Chem Phys. 2021. PMID: 34494640 Free PMC article.