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BCG revaccination in adults enhances pro-inflammatory markers of trained immunity along with anti-inflammatory pathways.
Ahmed A, Tripathi H, van Meijgaarden KE, Kumar NC, Adiga V, Rakshit S, Parthiban C, Eveline J S, D'Souza G, Dias M, Ottenhoff THM, Netea MG, Joosten SA, Vyakarnam A. Ahmed A, et al. Among authors: kumar nc. iScience. 2023 Sep 9;26(10):107889. doi: 10.1016/j.isci.2023.107889. eCollection 2023 Oct 20. iScience. 2023. PMID: 37817935 Free PMC article.
Evidence for the heterologous benefits of prior BCG vaccination on COVISHIELD™ vaccine-induced immune responses in SARS-CoV-2 seronegative young Indian adults.
Rakshit S, Adiga V, Ahmed A, Parthiban C, Chetan Kumar N, Dwarkanath P, Shivalingaiah S, Rao S, D'Souza G, Dias M, Maguire TJA, Doores KJ, Zoodsma M, Geckin B, Dasgupta P, Babji S, van Meijgaarden KE, Joosten SA, Ottenhoff THM, Li Y, Netea MG, Stuart KD, De Rosa SC, McElrath MJ, Vyakarnam A. Rakshit S, et al. Among authors: chetan kumar n. Front Immunol. 2022 Oct 4;13:985938. doi: 10.3389/fimmu.2022.985938. eCollection 2022. Front Immunol. 2022. PMID: 36268023 Free PMC article.
BCG revaccination qualitatively and quantitatively enhances SARS-CoV-2 spike-specific neutralizing antibody and T cell responses induced by the COVISHIELD™ vaccine in SARS-CoV-2 seronegative young Indian adults.
Rakshit S, Adiga V, Ahmed A, Parthiban C, Kumar NC, Dwarkanath P, Shivalingaiah S, Rao S, D'Souza G, Dias M, Maguire TJA, Doores K, Dasgupta P, Babji S, Ottenhoff THM, Stuart KD, De Rosa S, McElrath MJ, Vyakarnam A. Rakshit S, et al. Among authors: kumar nc. Res Sq [Preprint]. 2022 Mar 2:rs.3.rs-1395683. doi: 10.21203/rs.3.rs-1395683/v1. Res Sq. 2022. PMID: 35262071 Free PMC article. Preprint.
Differences in Immune Responses in Individuals of Indian and European Origin: Relevance for the COVID-19 Pandemic.
Geckin B, Zoodsma M, Kilic G, Debisarun PA, Rakshit S, Adiga V, Ahmed A, Parthiban C, Kumar NC, D'Souza G, Baltissen MP, Martens JHA, Domínguez-Andrés J, Li Y, Vyakarnam A, Netea MG. Geckin B, et al. Among authors: kumar nc. Microbiol Spectr. 2023 Feb 13;11(2):e0023123. doi: 10.1128/spectrum.00231-23. Online ahead of print. Microbiol Spectr. 2023. PMID: 36779734 Free PMC article.
Polyfunctional CD4 T-cells correlating with neutralising antibody is a hallmark of COVISHIELDTM and COVAXIN® induced immunity in COVID-19 exposed Indians.
Rakshit S, Babji S, Parthiban C, Madhavan R, Adiga V, J SE, Chetan Kumar N, Ahmed A, Shivalingaiah S, Shashikumar N, V M, Johnson AR, Ramesh N, B RG, Asokan M, Mayor S, Kang G, D'souza G, Dias M, Vyakarnam A. Rakshit S, et al. Among authors: chetan kumar n. NPJ Vaccines. 2023 Sep 14;8(1):134. doi: 10.1038/s41541-023-00731-w. NPJ Vaccines. 2023. PMID: 37709772 Free PMC article.
Immune profiling reveals umbilical cord blood mononuclear cells from South India display an IL-8 dominant, CXCL-10 deficient polyfunctional monocyte response to pathogen-associated molecular patterns (PAMPs) that is distinct from adult blood cells.
Adiga V, Bindhu H, Ahmed A, Kumar NC, Tripathi H, D'Souza G, Dias M, Shivalingaiah S, Rao S, Shanti KN, Hawrylowicz C, Dwarkanath P, Vyakarnam A. Adiga V, et al. Among authors: kumar nc. Clin Exp Immunol. 2024 May 2:uxae034. doi: 10.1093/cei/uxae034. Online ahead of print. Clin Exp Immunol. 2024. PMID: 38695079