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The mixing method used to formulate lipid nanoparticles affects mRNA delivery efficacy and organ tropism.
Eur J Pharm Biopharm. 2023 Nov;192:126-135. doi: 10.1016/j.ejpb.2023.10.006. Epub 2023 Oct 12.
Eur J Pharm Biopharm. 2023.
PMID: 37838143
Free PMC article.
Lipid nanoparticle structure and delivery route during pregnancy dictate mRNA potency, immunogenicity, and maternal and fetal outcomes.
Chaudhary N, Newby AN, Arral ML, Yerneni SS, LoPresti ST, Doerfler R, Petersen DMS, Montoya C, Kim JS, Fox B, Coon T, Malaney A, Sadovsky Y, Whitehead KA.
Chaudhary N, et al. Among authors: petersen dms.
Proc Natl Acad Sci U S A. 2024 Mar 12;121(11):e2307810121. doi: 10.1073/pnas.2307810121. Epub 2024 Mar 4.
Proc Natl Acad Sci U S A. 2024.
PMID: 38437545
Free PMC article.
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