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Year Number of Results
2006 1
2009 2
2010 1
2011 1
2012 2
2013 3
2014 1
2015 2
2016 2
2017 2
2018 1
2019 3
2020 1
2021 1
2022 2
2023 4
2024 1

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27 results

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Page 1
Preclinical characterization and target validation of the antimalarial pantothenamide MMV693183.
de Vries LE, Jansen PAM, Barcelo C, Munro J, Verhoef JMJ, Pasaje CFA, Rubiano K, Striepen J, Abla N, Berning L, Bolscher JM, Demarta-Gatsi C, Henderson RWM, Huijs T, Koolen KMJ, Tumwebaze PK, Yeo T, Aguiar ACC, Angulo-Barturen I, Churchyard A, Baum J, Fernández BC, Fuchs A, Gamo FJ, Guido RVC, Jiménez-Diaz MB, Pereira DB, Rochford R, Roesch C, Sanz LM, Trevitt G, Witkowski B, Wittlin S, Cooper RA, Rosenthal PJ, Sauerwein RW, Schalkwijk J, Hermkens PHH, Bonnert RV, Campo B, Fidock DA, Llinás M, Niles JC, Kooij TWA, Dechering KJ. de Vries LE, et al. Among authors: jansen pam. Nat Commun. 2022 Apr 20;13(1):2158. doi: 10.1038/s41467-022-29688-5. Nat Commun. 2022. PMID: 35444200 Free PMC article.
Gram-positive anaerobic cocci guard skin homeostasis by regulating host-defense mechanisms.
van der Krieken DA, Rikken G, Ederveen THA, Jansen PAM, Rodijk-Olthuis D, Meesters LD, van Vlijmen-Willems IMJJ, van Cranenbroek B, van der Molen RG, Schalkwijk J, van den Bogaard EH, Zeeuwen PLJM. van der Krieken DA, et al. Among authors: jansen pam. iScience. 2023 Mar 23;26(4):106483. doi: 10.1016/j.isci.2023.106483. eCollection 2023 Apr 21. iScience. 2023. PMID: 37096035 Free PMC article.
Antimalarial pantothenamide metabolites target acetyl-coenzyme A biosynthesis in Plasmodium falciparum.
Schalkwijk J, Allman EL, Jansen PAM, de Vries LE, Verhoef JMJ, Jackowski S, Botman PNM, Beuckens-Schortinghuis CA, Koolen KMJ, Bolscher JM, Vos MW, Miller K, Reeves SA, Pett H, Trevitt G, Wittlin S, Scheurer C, Sax S, Fischli C, Angulo-Barturen I, Jiménez-Diaz MB, Josling G, Kooij TWA, Bonnert R, Campo B, Blaauw RH, Rutjes FPJT, Sauerwein RW, Llinás M, Hermkens PHH, Dechering KJ. Schalkwijk J, et al. Among authors: jansen pam. Sci Transl Med. 2019 Sep 18;11(510):eaas9917. doi: 10.1126/scitranslmed.aas9917. Sci Transl Med. 2019. PMID: 31534021
Psoriasis-Associated Late Cornified Envelope (LCE) Proteins Have Antibacterial Activity.
Niehues H, Tsoi LC, van der Krieken DA, Jansen PAM, Oortveld MAW, Rodijk-Olthuis D, van Vlijmen IMJJ, Hendriks WJAJ, Helder RW, Bouwstra JA, van den Bogaard EH, Stuart PE, Nair RP, Elder JT, Zeeuwen PLJM, Schalkwijk J. Niehues H, et al. Among authors: jansen pam. J Invest Dermatol. 2017 Nov;137(11):2380-2388. doi: 10.1016/j.jid.2017.06.003. Epub 2017 Jun 17. J Invest Dermatol. 2017. PMID: 28634035 Free PMC article.
Investigations into the FLG Null Phenotype: Showcasing the Methodology for CRISPR/Cas9 Editing of Human Keratinocytes.
Smits JPH, van den Brink NJM, Meesters LD, Hamdaoui H, Niehues H, Jansen PAM, van Vlijmen-Willems IMJJ, Rodijk-Olthuis D, Evrard C, Poumay Y, van Geel M, Hendriks WJAJ, Schalkwijk J, Zeeuwen PLJM, van den Bogaard EH. Smits JPH, et al. Among authors: jansen pam. J Invest Dermatol. 2023 Aug;143(8):1520-1528.e5. doi: 10.1016/j.jid.2023.02.021. Epub 2023 Mar 7. J Invest Dermatol. 2023. PMID: 36893939 Free article.
Novel pantothenate derivatives for anti-malarial chemotherapy.
Pett HE, Jansen PA, Hermkens PH, Botman PN, Beuckens-Schortinghuis CA, Blaauw RH, Graumans W, van de Vegte-Bolmer M, Koolen KM, Rutjes FP, Dechering KJ, Sauerwein RW, Schalkwijk J. Pett HE, et al. Among authors: jansen pa. Malar J. 2015 Apr 18;14:169. doi: 10.1186/s12936-015-0673-8. Malar J. 2015. PMID: 25927675 Free PMC article.
Stable pantothenamide bioisosteres: novel antibiotics for Gram-positive bacteria.
Jansen PAM, van der Krieken DA, Botman PNM, Blaauw RH, Cavina L, Raaijmakers EM, de Heuvel E, Sandrock J, Pennings LJ, Hermkens PHH, Zeeuwen PLJM, Rutjes FPJT, Schalkwijk J. Jansen PAM, et al. J Antibiot (Tokyo). 2019 Sep;72(9):682-692. doi: 10.1038/s41429-019-0196-6. Epub 2019 Jun 6. J Antibiot (Tokyo). 2019. PMID: 31171848 Free PMC article.
CYSRT1: An Antimicrobial Epidermal Protein that Can Interact with Late Cornified Envelope Proteins.
Niehues H, Rikken G, Kersten FFJ, Eeftens JM, van Vlijmen-Willems IMJJ, Rodijk-Olthuis D, Jansen PAM, Hendriks WJAJ, Ederveen THA, Schalkwijk J, van den Bogaard EH, Zeeuwen PLJM. Niehues H, et al. Among authors: jansen pam. J Invest Dermatol. 2023 Aug;143(8):1498-1508.e7. doi: 10.1016/j.jid.2023.01.022. Epub 2023 Feb 15. J Invest Dermatol. 2023. PMID: 36804407 Free article.
Deficiency of the human cysteine protease inhibitor cystatin M/E causes hypotrichosis and dry skin.
van den Bogaard EHJ, van Geel M, van Vlijmen-Willems IMJJ, Jansen PAM, Peppelman M, van Erp PEJ, Atalay S, Venselaar H, Simon MEH, Joosten M, Schalkwijk J, Zeeuwen PLJM. van den Bogaard EHJ, et al. Among authors: jansen pam. Genet Med. 2019 Jul;21(7):1559-1567. doi: 10.1038/s41436-018-0355-3. Epub 2018 Nov 14. Genet Med. 2019. PMID: 30425301 Free PMC article.
27 results