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Page 1
Validation of a New Methodology to Create Oral Drugs beyond the Rule of 5 for Intracellular Tough Targets.
J Am Chem Soc. 2023 Nov 8;145(44):24035-24051. doi: 10.1021/jacs.3c07145. Epub 2023 Oct 24.
J Am Chem Soc. 2023.
PMID: 37874670
EOS789, a broad-spectrum inhibitor of phosphate transport, is safe with an indication of efficacy in a phase 1b randomized crossover trial in hemodialysis patients.
Hill Gallant KM, Stremke ER, Trevino LL, Moorthi RN, Doshi S, Wastney ME, Hisada N, Sato J, Ogita Y, Fujii N, Matsuda Y, Kake T, Moe SM.
Hill Gallant KM, et al. Among authors: hisada n.
Kidney Int. 2021 May;99(5):1225-1233. doi: 10.1016/j.kint.2020.09.035. Epub 2020 Oct 31.
Kidney Int. 2021.
PMID: 33137340
Free PMC article.
Clinical Trial.
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Low-molecular-weight hyaluronan permeates through human intestinal Caco-2 cell monolayers via the paracellular pathway.
Hisada N, Satsu H, Mori A, Totsuka M, Kamei J, Nozawa T, Shimizu M.
Hisada N, et al.
Biosci Biotechnol Biochem. 2008 Apr;72(4):1111-4. doi: 10.1271/bbb.70748. Epub 2008 Apr 7.
Biosci Biotechnol Biochem. 2008.
PMID: 18391466
Free article.
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Permeation of disaccharides derived from chondroitin sulfate through human intestinal Caco-2 cell monolayers via the paracellular pathway.
Jin M, Satsu H, Yamada K, Hisada N, Totsuka M, Shimizu M.
Jin M, et al. Among authors: hisada n.
Biosci Biotechnol Biochem. 2010;74(6):1243-9. doi: 10.1271/bbb.100075. Epub 2010 Jun 7.
Biosci Biotechnol Biochem. 2010.
PMID: 20530904
Free article.
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Characterizing the dissolution profiles of supersaturable salts, cocrystals, and solvates to enhance in vivo oral absorption.
Hisada N, Takano R, Takata N, Shiraki K, Ueto T, Tanida S, Kataoka M, Yamashita S.
Hisada N, et al.
Eur J Pharm Biopharm. 2016 Jun;103:192-199. doi: 10.1016/j.ejpb.2016.04.004. Epub 2016 Apr 7.
Eur J Pharm Biopharm. 2016.
PMID: 27060622
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