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Year | Number of Results |
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2020 | 1 |
2021 | 1 |
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2023 | 3 |
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Page 1
Plasma protein-mediated uptake and contradictions to the free drug hypothesis: a critical review.
Drug Metab Rev. 2023 Aug;55(3):205-238. doi: 10.1080/03602532.2023.2195133. Epub 2023 Apr 12.
Drug Metab Rev. 2023.
PMID: 36971325
Review.
Antibody-drug conjugates as targeted therapies: Are we there yet? A critical review of the current clinical landscape.
Tarcsa E, Guffroy MR, Falahatpisheh H, Phipps C, Kalvass JC.
Tarcsa E, et al. Among authors: kalvass jc.
Drug Discov Today Technol. 2020 Dec;37:13-22. doi: 10.1016/j.ddtec.2020.07.002. Epub 2020 Sep 29.
Drug Discov Today Technol. 2020.
PMID: 34895651
Review.
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Selective MCL-1 inhibitor ABBV-467 is efficacious in tumor models but is associated with cardiac troponin increases in patients.
Yuda J, Will C, Phillips DC, Abraham L, Alvey C, Avigdor A, Buck W, Besenhofer L, Boghaert E, Cheng D, Cojocari D, Doyle K, Hansen TM, Huang K, Johnson EF, Judd AS, Judge RA, Kalvass JC, Kunzer A, Lam LT, Li R, Martin RL, Mastracchio A, Mitten M, Petrich A, Wang J, Ward JE, Zhang H, Wang X, Wolff JE, Bell-McGuinn KM, Souers AJ.
Yuda J, et al. Among authors: kalvass jc.
Commun Med (Lond). 2023 Oct 25;3(1):154. doi: 10.1038/s43856-023-00380-z.
Commun Med (Lond). 2023.
PMID: 37880389
Free PMC article.
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Expanding the Repertoire for "Large Small Molecules": Prodrug ABBV-167 Efficiently Converts to Venetoclax with Reduced Food Effect in Healthy Volunteers.
Salem AH, Tao ZF, Bueno OF, Chen J, Chen S, Edalji R, Elmore SW, Fournier KM, Harper KC, Hong R, Jenkins GJ, Ji J, Judge RA, Kalvass JC, Klix RC, Ku YY, Leverson JD, Marks RA, Marsh KC, Menon RM, Park CH, Phillips DC, Pu YM, Rosenberg SH, Sanzgiri YD, Sheikh AY, Shi Y, Stolarik D, Suleiman AA, Wang X, Zhang GGZ, Catron ND, Souers AJ.
Salem AH, et al. Among authors: kalvass jc.
Mol Cancer Ther. 2021 Jun;20(6):999-1008. doi: 10.1158/1535-7163.MCT-21-0077. Epub 2021 Mar 30.
Mol Cancer Ther. 2021.
PMID: 33785651
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Discovery of (R)-(3-fluoropyrrolidin-1-yl)(6-((5-(trifluoromethyl)pyridin-2-yl)oxy)quinolin-2-yl)methanone (ABBV-318) and analogs as small molecule Nav1.7/ Nav1.8 blockers for the treatment of pain.
Patel MV, Peltier HM, Matulenko MA, Koenig JR, C Scanio MJ, Gum RJ, El-Kouhen OF, Fricano MM, Lundgaard GL, Neelands T, Zhang XF, Zhan C, Pai M, Ghoreishi-Haack N, Hudzik T, Gintant G, Martin R, McGaraughty S, Xu J, Bow D, Kalvass JC, Kym PR, DeGoey DA, Kort ME.
Patel MV, et al. Among authors: kalvass jc.
Bioorg Med Chem. 2022 Jun 1;63:116743. doi: 10.1016/j.bmc.2022.116743. Epub 2022 Apr 11.
Bioorg Med Chem. 2022.
PMID: 35436748
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Assumptions Underlying Hepatic Clearance Models: Recognizing the Influence of Saturable Protein Binding on Driving Force Concentration and Discrimination Between Models of Hepatic Clearance.
Schulz Pauly JA, Wang J, Phipps CJ, Kalvass JC.
Schulz Pauly JA, et al.
Drug Metab Dispos. 2023 Aug;51(8):1046-1052. doi: 10.1124/dmd.123.001326. Epub 2023 May 15.
Drug Metab Dispos. 2023.
PMID: 37188529
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