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Global analysis of putative phospholipases in Plasmodium falciparum reveals an essential role of the phosphoinositide-specific phospholipase C in parasite maturation.
Burda PC, Ramaprasad A, Bielfeld S, Pietsch E, Woitalla A, Söhnchen C, Singh MN, Strauss J, Sait A, Collinson LM, Schwudke D, Blackman MJ, Gilberger TW. Burda PC, et al. Among authors: bielfeld s. mBio. 2023 Aug 31;14(4):e0141323. doi: 10.1128/mbio.01413-23. Epub 2023 Jul 25. mBio. 2023. PMID: 37489900 Free PMC article.
A patatin-like phospholipase is important for mitochondrial function in malaria parasites.
Pietsch E, Ramaprasad A, Bielfeld S, Wohlfarter Y, Maco B, Niedermüller K, Wilcke L, Kloehn J, Keller MA, Soldati-Favre D, Blackman MJ, Gilberger T-W, Burda P-C. Pietsch E, et al. Among authors: bielfeld s. mBio. 2023 Oct 26;14(6):e0171823. doi: 10.1128/mbio.01718-23. Online ahead of print. mBio. 2023. PMID: 37882543 Free PMC article.
The essential malaria protein PfCyRPA targets glycans to invade erythrocytes.
Day CJ, Favuzza P, Bielfeld S, Haselhorst T, Seefeldt L, Hauser J, Shewell LK, Flueck C, Poole J, Jen FE, Schäfer A, Dangy JP, Gilberger TW, França CT, Duraisingh MT, Tamborrini M, Brancucci NMB, Grüring C, Filarsky M, Jennings MP, Pluschke G. Day CJ, et al. Among authors: bielfeld s. Cell Rep. 2024 Apr 23;43(4):114012. doi: 10.1016/j.celrep.2024.114012. Epub 2024 Apr 3. Cell Rep. 2024. PMID: 38573856 Free article.