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Page 1
Discovery and Clinical Proof-of-Concept of RLY-2608, a First-in-Class Mutant-Selective Allosteric PI3Kα Inhibitor That Decouples Antitumor Activity from Hyperinsulinemia.
Cancer Discov. 2024 Feb 8;14(2):240-257. doi: 10.1158/2159-8290.CD-23-0944.
Cancer Discov. 2024.
PMID: 37916956
Free PMC article.
Ensemble cryo-EM reveals conformational states of the nsp13 helicase in the SARS-CoV-2 helicase replication-transcription complex.
Chen J, Wang Q, Malone B, Llewellyn E, Pechersky Y, Maruthi K, Eng ET, Perry JK, Campbell EA, Shaw DE, Darst SA.
Chen J, et al. Among authors: pechersky y.
Nat Struct Mol Biol. 2022 Mar;29(3):250-260. doi: 10.1038/s41594-022-00734-6. Epub 2022 Mar 8.
Nat Struct Mol Biol. 2022.
PMID: 35260847
Free PMC article.
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Structural mechanism for Bruton's tyrosine kinase activation at the cell membrane.
Wang Q, Pechersky Y, Sagawa S, Pan AC, Shaw DE.
Wang Q, et al. Among authors: pechersky y.
Proc Natl Acad Sci U S A. 2019 May 7;116(19):9390-9399. doi: 10.1073/pnas.1819301116. Epub 2019 Apr 24.
Proc Natl Acad Sci U S A. 2019.
PMID: 31019091
Free PMC article.
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The Cremeomycin Biosynthetic Gene Cluster Encodes a Pathway for Diazo Formation.
Waldman AJ, Pechersky Y, Wang P, Wang JX, Balskus EP.
Waldman AJ, et al. Among authors: pechersky y.
Chembiochem. 2015 Oct 12;16(15):2172-5. doi: 10.1002/cbic.201500407. Epub 2015 Sep 14.
Chembiochem. 2015.
PMID: 26278892
Free PMC article.
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