Endotype evaluation of Hispanic/Latinx-American patients with chronic rhinosinusitis with nasal polyps

Arthur W Wu; Dennis M Tang; Kevin Hur; Aria Jafari; Philip G Chen; Masayoshi Takashima; Elena E Chang; Bonnie Balzer; Anna Mathew; Mukul Divatia; Haodong Xu; Juliana Robledo; Luv Amin; Benjamin Tam; David J Cvancara; Amisheila G Kinua; Tariq A Syed; Dominique L Paderin; Missael Vasquez; Omar G Ahmed

doi:10.1002/alr.23298

Endotype evaluation of Hispanic/Latinx-American patients with chronic rhinosinusitis with nasal polyps

Int Forum Allergy Rhinol. 2024 May;14(5):981-985. doi: 10.1002/alr.23298. Epub 2023 Nov 7.

Authors

Arthur W Wu¹, Dennis M Tang¹, Kevin Hur², Aria Jafari³, Philip G Chen⁴, Masayoshi Takashima⁵, Elena E Chang⁶, Bonnie Balzer⁶, Anna Mathew⁷, Mukul Divatia⁸, Haodong Xu⁹, Juliana Robledo¹⁰, Luv Amin¹, Benjamin Tam², David J Cvancara³, Amisheila G Kinua⁴, Tariq A Syed⁵, Dominique L Paderin⁵, Missael Vasquez¹, Omar G Ahmed⁵

Affiliations

¹ Division of Otolaryngology-Head & Neck Surgery, Cedars-Sinai Medical Center, Los Angeles, California, USA.
² Department of Otolaryngology-Head & Neck Surgery, University of Southern California, Los Angeles, California, USA.
³ Department of Otolaryngology-Head & Neck Surgery, University of Washington, Seattle, Washington, USA.
⁴ Department of Otolaryngology-Head & Neck Surgery, University of Texas-San Antonio, San Antonio, Texas, USA.
⁵ Department of Otolaryngology-Head & Neck Surgery, Houston Methodist Hospital, Houston, Texas, USA.
⁶ Department of Pathology, Cedars-Sinai Medical Center, Los Angeles, California, USA.
⁷ Department of Pathology, University of Southern California, Los Angeles, California, USA.
⁸ Department of Pathology, Houston Methodist Hospital, Houston, Texas, USA.
⁹ Department of Pathology, University of Washington, Seattle, Washington, USA.
¹⁰ Department of Pathology, University of Texas Health San Antonio, San Antonio, Texas, USA.

PMID: 37933596
DOI: 10.1002/alr.23298

Abstract

Hispanic-American patients with chronic rhinosinusitis with nasal polyps have a comparable level of tissue eosinophilia compared to their Caucasian counterparts in the United States. Mixed inflammation involving both neutrophils and eosinophils is more common in this population compared to Caucasians. Findings from this study may indicate that Hispanic-American patients have a unique endotype or endotypes that deserves further investigation.

Keywords: Allergic; Chronic Rhinosinusitis; Eosinophilic rhinitis and nasal polyposis; sinusitis.

MeSH terms

Adult
Chronic Disease
Eosinophilia / ethnology
Eosinophils / immunology
Female
Hispanic or Latino*
Humans
Male
Middle Aged
Nasal Polyps* / ethnology
Neutrophils / immunology
Rhinosinusitis / ethnology
Rhinosinusitis / immunology
United States / epidemiology