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Page 1
Protein aggregation and calcium dysregulation are hallmarks of familial Parkinson's disease in midbrain dopaminergic neurons.
Virdi GS, Choi ML, Evans JR, Yao Z, Athauda D, Strohbuecker S, Nirujogi RS, Wernick AI, Pelegrina-Hidalgo N, Leighton C, Saleeb RS, Kopach O, Alrashidi H, Melandri D, Perez-Lloret J, Angelova PR, Sylantyev S, Eaton S, Heales S, Rusakov DA, Alessi DR, Kunath T, Horrocks MH, Abramov AY, Patani R, Gandhi S. Virdi GS, et al. Among authors: leighton c. NPJ Parkinsons Dis. 2022 Nov 24;8(1):162. doi: 10.1038/s41531-022-00423-7. NPJ Parkinsons Dis. 2022. PMID: 36424392 Free PMC article.
Single-Molecule Two-Color Coincidence Detection of Unlabeled alpha-Synuclein Aggregates.
Chappard A, Leighton C, Saleeb RS, Jeacock K, Ball SR, Morris K, Kantelberg O, Lee JE, Zacco E, Pastore A, Sunde M, Clarke DJ, Downey P, Kunath T, Horrocks MH. Chappard A, et al. Among authors: leighton c. Angew Chem Int Ed Engl. 2023 Apr 3;62(15):e202216771. doi: 10.1002/anie.202216771. Epub 2023 Feb 28. Angew Chem Int Ed Engl. 2023. PMID: 36762870 Free PMC article.
Two-color coincidence single-molecule pulldown for the specific detection of disease-associated protein aggregates.
Saleeb RS, Leighton C, Lee JE, O'Shaughnessy J, Jeacock K, Chappard A, Cumberland R, Zhao T, Ball SR, Sunde M, Clarke DJ, Piché K, McPhail JA, Louwrier A, Angers R, Gandhi S, Downey P, Kunath T, Horrocks MH. Saleeb RS, et al. Among authors: leighton c. Sci Adv. 2023 Nov 17;9(46):eadi7359. doi: 10.1126/sciadv.adi7359. Epub 2023 Nov 15. Sci Adv. 2023. PMID: 37967183 Free PMC article.
Single-Molecule Two-Color Coincidence Detection of Unlabeled alpha-Synuclein Aggregates.
Chappard A, Leighton C, Saleeb RS, Jeacock K, Ball SR, Morris K, Kantelberg O, Lee JE, Zacco E, Pastore A, Sunde M, Clarke DJ, Downey P, Kunath T, Horrocks MH. Chappard A, et al. Among authors: leighton c. Angew Chem Weinheim Bergstr Ger. 2023 Apr 3;135(15):e202216771. doi: 10.1002/ange.202216771. Epub 2023 Feb 28. Angew Chem Weinheim Bergstr Ger. 2023. PMID: 38516037 Free PMC article.