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CDK4/6 inhibitor-mediated cell overgrowth triggers osmotic and replication stress to promote senescence.
Mol Cell. 2023 Nov 16;83(22):4062-4077.e5. doi: 10.1016/j.molcel.2023.10.016. Epub 2023 Nov 16.
Mol Cell. 2023.
PMID: 37977118
Free article.
Oncogenic signals prime cancer cells for toxic cell overgrowth during a G1 cell cycle arrest.
Foy R, Crozier L, Pareri AU, Valverde JM, Park BH, Ly T, Saurin AT.
Foy R, et al.
Mol Cell. 2023 Nov 16;83(22):4047-4061.e6. doi: 10.1016/j.molcel.2023.10.020. Epub 2023 Nov 16.
Mol Cell. 2023.
PMID: 37977117
Free article.
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The search for CDK4/6 inhibitor biomarkers has been hampered by inappropriate proliferation assays.
Foy R, Lew KX, Saurin AT.
Foy R, et al.
NPJ Breast Cancer. 2024 Mar 4;10(1):19. doi: 10.1038/s41523-024-00624-8.
NPJ Breast Cancer. 2024.
PMID: 38438376
Free PMC article.
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CDK4/6 inhibitors induce replication stress to cause long-term cell cycle withdrawal.
Crozier L, Foy R, Mouery BL, Whitaker RH, Corno A, Spanos C, Ly T, Gowen Cook J, Saurin AT.
Crozier L, et al. Among authors: foy r.
EMBO J. 2022 Mar 15;41(6):e108599. doi: 10.15252/embj.2021108599. Epub 2022 Jan 17.
EMBO J. 2022.
PMID: 35037284
Free PMC article.
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