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Asparagine couples mitochondrial respiration to ATF4 activity and tumor growth.
Krall AS, Mullen PJ, Surjono F, Momcilovic M, Schmid EW, Halbrook CJ, Thambundit A, Mittelman SD, Lyssiotis CA, Shackelford DB, Knott SRV, Christofk HR. Krall AS, et al. Among authors: schmid ew. Cell Metab. 2021 May 4;33(5):1013-1026.e6. doi: 10.1016/j.cmet.2021.02.001. Epub 2021 Feb 19. Cell Metab. 2021. PMID: 33609439 Free PMC article.
Extracellular Matrix Remodeling Regulates Glucose Metabolism through TXNIP Destabilization.
Sullivan WJ, Mullen PJ, Schmid EW, Flores A, Momcilovic M, Sharpley MS, Jelinek D, Whiteley AE, Maxwell MB, Wilde BR, Banerjee U, Coller HA, Shackelford DB, Braas D, Ayer DE, de Aguiar Vallim TQ, Lowry WE, Christofk HR. Sullivan WJ, et al. Among authors: schmid ew. Cell. 2018 Sep 20;175(1):117-132.e21. doi: 10.1016/j.cell.2018.08.017. Epub 2018 Sep 6. Cell. 2018. PMID: 30197082 Free PMC article.
SARS-CoV-2 infection rewires host cell metabolism and is potentially susceptible to mTORC1 inhibition.
Mullen PJ, Garcia G Jr, Purkayastha A, Matulionis N, Schmid EW, Momcilovic M, Sen C, Langerman J, Ramaiah A, Shackelford DB, Damoiseaux R, French SW, Plath K, Gomperts BN, Arumugaswami V, Christofk HR. Mullen PJ, et al. Among authors: schmid ew. Nat Commun. 2021 Mar 25;12(1):1876. doi: 10.1038/s41467-021-22166-4. Nat Commun. 2021. PMID: 33767183 Free PMC article.