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Page 1
HIF-1α and HIF-2α redundantly promote retinal neovascularization in patients with ischemic retinal disease.
Zhang J, Qin Y, Martinez M, Flores-Bellver M, Rodrigues M, Dinabandhu A, Cao X, Deshpande M, Qin Y, Aparicio-Domingo S, Rui Y, Tzeng SY, Salman S, Yuan J, Scott AW, Green JJ, Canto-Soler MV, Semenza GL, Montaner S, Sodhi A. Zhang J, et al. Among authors: aparicio domingo s. J Clin Invest. 2021 Jun 15;131(12):e139202. doi: 10.1172/JCI139202. J Clin Invest. 2021. PMID: 34128478 Free PMC article.
PAI-1 is a vascular cell-specific HIF-2-dependent angiogenic factor that promotes retinal neovascularization in diabetic patients.
Qin Y, Zhang J, Babapoor-Farrokhran S, Applewhite B, Deshpande M, Megarity H, Flores-Bellver M, Aparicio-Domingo S, Ma T, Rui Y, Tzeng SY, Green JJ, Canto-Soler MV, Montaner S, Sodhi A. Qin Y, et al. Among authors: aparicio domingo s. Sci Adv. 2022 Mar 4;8(9):eabm1896. doi: 10.1126/sciadv.abm1896. Epub 2022 Mar 2. Sci Adv. 2022. PMID: 35235351 Free PMC article.
Extracellular vesicles released by human retinal pigment epithelium mediate increased polarised secretion of drusen proteins in response to AMD stressors.
Flores-Bellver M, Mighty J, Aparicio-Domingo S, Li KV, Shi C, Zhou J, Cobb H, McGrath P, Michelis G, Lenhart P, Bilousova G, Heissel S, Rudy MJ, Coughlan C, Goodspeed AE, Becerra SP, Redenti S, Canto-Soler MV. Flores-Bellver M, et al. Among authors: aparicio domingo s. J Extracell Vesicles. 2021 Nov;10(13):e12165. doi: 10.1002/jev2.12165. J Extracell Vesicles. 2021. PMID: 34750957 Free PMC article.
Single-cell transcriptome analysis of xenotransplanted human retinal organoids defines two migratory cell populations of nonretinal origin.
Liu YV, Santiago CP, Sogunro A, Konar GJ, Hu MW, McNally MM, Lu YC, Flores-Bellver M, Aparicio-Domingo S, Li KV, Li ZL, Agakishiev D, Hadyniak SE, Hussey KA, Creamer TJ, Orzolek LD, Teng D, Canto-Soler MV, Qian J, Jiang Z, Johnston RJ Jr, Blackshaw S, Singh MS. Liu YV, et al. Among authors: aparicio domingo s. Stem Cell Reports. 2023 May 9;18(5):1138-1154. doi: 10.1016/j.stemcr.2023.04.004. Stem Cell Reports. 2023. PMID: 37163980 Free PMC article.
Pathologic vs. protective roles of hypoxia-inducible factor 1 in RPE and photoreceptors in wet vs. dry age-related macular degeneration.
Babapoor-Farrokhran S, Qin Y, Flores-Bellver M, Niu Y, Bhutto IA, Aparicio-Domingo S, Guo C, Rodrigues M, Domashevich T, Deshpande M, Megarity H, Chopde R, Eberhart CG, Canto-Soler V, Montaner S, Sodhi A. Babapoor-Farrokhran S, et al. Among authors: aparicio domingo s. Proc Natl Acad Sci U S A. 2023 Dec 12;120(50):e2302845120. doi: 10.1073/pnas.2302845120. Epub 2023 Dec 6. Proc Natl Acad Sci U S A. 2023. PMID: 38055741 Free PMC article.
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