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Clonal Selection with RAS Pathway Activation Mediates Secondary Clinical Resistance to Selective FLT3 Inhibition in Acute Myeloid Leukemia.
McMahon CM, Ferng T, Canaani J, Wang ES, Morrissette JJD, Eastburn DJ, Pellegrino M, Durruthy-Durruthy R, Watt CD, Asthana S, Lasater EA, DeFilippis R, Peretz CAC, McGary LHF, Deihimi S, Logan AC, Luger SM, Shah NP, Carroll M, Smith CC, Perl AE. McMahon CM, et al. Cancer Discov. 2019 Aug;9(8):1050-1063. doi: 10.1158/2159-8290.CD-18-1453. Epub 2019 May 14. Cancer Discov. 2019. PMID: 31088841
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DeFilippis RA, Tlsty TD. DeFilippis RA, et al. Cancer Discov. 2012 Dec;2(12):1084-6. doi: 10.1158/2159-8290.CD-12-0434. Cancer Discov. 2012. PMID: 23230186 Free PMC article.
Overcoming Secondary Mutations of Type II Kinase Inhibitors.
Wang X, DeFilippis RA, Yan W, Shah NP, Li HY. Wang X, et al. Among authors: defilippis ra. J Med Chem. 2024 Jun 5. doi: 10.1021/acs.jmedchem.3c01629. Online ahead of print. J Med Chem. 2024. PMID: 38837951 Review.
Venetoclax combines synergistically with FLT3 inhibition to effectively target leukemic cells in FLT3-ITD+ acute myeloid leukemia models.
Singh Mali R, Zhang Q, DeFilippis RA, Cavazos A, Kuruvilla VM, Raman J, Mody V, Choo EF, Dail M, Shah NP, Konopleva M, Sampath D, Lasater EA. Singh Mali R, et al. Among authors: defilippis ra. Haematologica. 2021 Apr 1;106(4):1034-1046. doi: 10.3324/haematol.2019.244020. Haematologica. 2021. PMID: 32414851 Free PMC article.
15 results