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Page 1
An LNA-amide modification that enhances the cell uptake and activity of phosphorothioate exon-skipping oligonucleotides.
Nat Commun. 2022 Jul 12;13(1):4036. doi: 10.1038/s41467-022-31636-2.
Nat Commun. 2022.
PMID: 35821218
Free PMC article.
A New 1,5-Disubstituted Triazole DNA Backbone Mimic with Enhanced Polymerase Compatibility.
Epple S, Modi A, Baker YR, Wȩgrzyn E, Traoré D, Wanat P, Tyburn AES, Shivalingam A, Taemaitree L, El-Sagheer AH, Brown T.
Epple S, et al.
J Am Chem Soc. 2021 Oct 6;143(39):16293-16301. doi: 10.1021/jacs.1c08057. Epub 2021 Sep 21.
J Am Chem Soc. 2021.
PMID: 34546729
Free PMC article.
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Artificial nucleic acid backbones and their applications in therapeutics, synthetic biology and biotechnology.
Epple S, El-Sagheer AH, Brown T.
Epple S, et al.
Emerg Top Life Sci. 2021 Nov 12;5(5):691-697. doi: 10.1042/ETLS20210169.
Emerg Top Life Sci. 2021.
PMID: 34297063
Free PMC article.
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Modified minimal-size fragments of heparan sulfate as inhibitors of endosulfatase-2 (Sulf-2).
Kennett A, Epple S, van der Valk G, Georgiou I, Gout E, Vivès RR, Russell AJ.
Kennett A, et al. Among authors: epple s.
Chem Commun (Camb). 2024 Jan 4;60(4):436-439. doi: 10.1039/d3cc02565a.
Chem Commun (Camb). 2024.
PMID: 38086706
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Synthesis and biophysical properties of carbamate-locked nucleic acid (LNA) oligonucleotides with potential antisense applications.
Thorpe C, Epple S, Woods B, El-Sagheer AH, Brown T.
Thorpe C, et al. Among authors: epple s.
Org Biomol Chem. 2019 May 29;17(21):5341-5348. doi: 10.1039/c9ob00691e.
Org Biomol Chem. 2019.
PMID: 31099373
Free PMC article.
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Consecutive 5'- and 3'-amide linkages stabilise antisense oligonucleotides and elicit an efficient RNase H response.
Epple S, Thorpe C, Baker YR, El-Sagheer AH, Brown T.
Epple S, et al.
Chem Commun (Camb). 2020 May 21;56(41):5496-5499. doi: 10.1039/d0cc00444h.
Chem Commun (Camb). 2020.
PMID: 32292963
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Correction: Modified minimal-size fragments of heparan sulfate as inhibitors of endosulfatase-2 (Sulf-2).
Kennett A, Epple S, van der Valk G, Georgiou I, Gout E, Vivès RR, Russell AJ.
Kennett A, et al. Among authors: epple s.
Chem Commun (Camb). 2024 Apr 23;60(34):4617. doi: 10.1039/d4cc90123a.
Chem Commun (Camb). 2024.
PMID: 38602132
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