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Inhibition of ATGL alleviates MASH via impaired PPARα signalling that favours hydrophilic bile acid composition in mice.
Dixon ED, Claudel T, Nardo AD, Riva A, Fuchs C, Mlitz V, Busslinger G, Schnarnagl H, Stojakovic T, Senéca J, Hinteregger H, Grabner GF, Kratky D, Verkade H, Zimmermann R, Haemmerle G, Trauner M. Dixon ED, et al. Among authors: hinteregger h. J Hepatol. 2024 Sep 30:S0168-8278(24)02577-7. doi: 10.1016/j.jhep.2024.09.037. Online ahead of print. J Hepatol. 2024. PMID: 39357546 Free article.
Loss of lysosomal acid lipase results in mitochondrial dysfunction and fiber switch in skeletal muscles of mice.
Akhmetshina A, Bianco V, Bradić I, Korbelius M, Pirchheim A, Kuentzel KB, Eichmann TO, Hinteregger H, Kolb D, Habisch H, Liesinger L, Madl T, Sattler W, Radović B, Sedej S, Birner-Gruenberger R, Vujić N, Kratky D. Akhmetshina A, et al. Among authors: hinteregger h. Mol Metab. 2024 Jan;79:101869. doi: 10.1016/j.molmet.2023.101869. Epub 2023 Dec 30. Mol Metab. 2024. PMID: 38160938 Free PMC article.