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CRISPR/Cas9 screen in human iPSC-derived cortical neurons identifies NEK6 as a novel disease modifier of C9orf72 poly(PR) toxicity.
Guo W, Wang H, Kumar Tharkeshwar A, Couthouis J, Braems E, Masrori P, Van Schoor E, Fan Y, Ahuja K, Moisse M, Jacquemyn M, Furtado Madeiro da Costa R, Gajjar M, Balusu S, Tricot T, Fumagalli L, Hersmus N, Janky R, Impens F, Vanden Berghe P, Ho R, Thal DR, Vandenberghe R, Hegde ML, Chandran S, De Strooper B, Daelemans D, Van Damme P, Van Den Bosch L, Verfaillie C. Guo W, et al. Among authors: furtado madeiro da costa r. Alzheimers Dement. 2023 Apr;19(4):1245-1259. doi: 10.1002/alz.12760. Epub 2022 Aug 22. Alzheimers Dement. 2023. PMID: 35993441 Free PMC article.
Disruption of MAM integrity in mutant FUS oligodendroglial progenitors from hiPSCs.
Zhu Y, Burg T, Neyrinck K, Vervliet T, Nami F, Vervoort E, Ahuja K, Sassano ML, Chai YC, Tharkeshwar AK, De Smedt J, Hu H, Bultynck G, Agostinis P, Swinnen JV, Van Den Bosch L, da Costa RFM, Verfaillie C. Zhu Y, et al. Among authors: da costa rfm. Acta Neuropathol. 2024 Jan 3;147(1):6. doi: 10.1007/s00401-023-02666-x. Acta Neuropathol. 2024. PMID: 38170217 Free PMC article.
PU.1 drives specification of pluripotent stem cell-derived endothelial cells to LSEC-like cells.
De Smedt J, van Os EA, Talon I, Ghosh S, Toprakhisar B, Furtado Madeiro Da Costa R, Zaunz S, Vazquez MA, Boon R, Baatsen P, Smout A, Verhulst S, van Grunsven LA, Verfaillie CM. De Smedt J, et al. Among authors: furtado madeiro da costa r. Cell Death Dis. 2021 Jan 14;12(1):84. doi: 10.1038/s41419-020-03356-2. Cell Death Dis. 2021. PMID: 33446637 Free PMC article.
Protein acetylation sites mediated by Schistosoma mansoni GCN5.
de Moraes Maciel R, da Costa RF, de Oliveira FM, Rumjanek FD, Fantappié MR. de Moraes Maciel R, et al. Among authors: da costa rf. Biochem Biophys Res Commun. 2008 May 23;370(1):53-6. doi: 10.1016/j.bbrc.2008.03.022. Epub 2008 Mar 17. Biochem Biophys Res Commun. 2008. PMID: 18346457
Zika virus infection leads to mitochondrial failure, oxidative stress and DNA damage in human iPSC-derived astrocytes.
Ledur PF, Karmirian K, Pedrosa CDSG, Souza LRQ, Assis-de-Lemos G, Martins TM, Ferreira JCCG, de Azevedo Reis GF, Silva ES, Silva D, Salerno JA, Ornelas IM, Devalle S, Madeiro da Costa RF, Goto-Silva L, Higa LM, Melo A, Tanuri A, Chimelli L, Murata MM, Garcez PP, Filippi-Chiela EC, Galina A, Borges HL, Rehen SK. Ledur PF, et al. Among authors: madeiro da costa rf. Sci Rep. 2020 Jan 27;10(1):1218. doi: 10.1038/s41598-020-57914-x. Sci Rep. 2020. PMID: 31988337 Free PMC article.