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Year | Number of Results |
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2020 | 2 |
2022 | 3 |
2023 | 3 |
2024 | 1 |
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Page 1
PROTAC chemical probes for histone deacetylase enzymes.
RSC Chem Biol. 2023 Jul 27;4(9):623-634. doi: 10.1039/d3cb00105a. eCollection 2023 Aug 30.
RSC Chem Biol. 2023.
PMID: 37654508
Free PMC article.
Review.
Bifunctional HDAC Therapeutics: One Drug to Rule Them All?
Smalley JP, Cowley SM, Hodgkinson JT.
Smalley JP, et al.
Molecules. 2020 Sep 24;25(19):4394. doi: 10.3390/molecules25194394.
Molecules. 2020.
PMID: 32987782
Free PMC article.
Review.
Item in Clipboard
A 'click' chemistry approach to novel entinostat (MS-275) based class I histone deacetylase proteolysis targeting chimeras.
Cross JM, Coulson ME, Smalley JP, Pytel WA, Ismail O, Trory JS, Cowley SM, Hodgkinson JT.
Cross JM, et al. Among authors: smalley jp.
RSC Med Chem. 2022 Nov 1;13(12):1634-1639. doi: 10.1039/d2md00199c. eCollection 2022 Dec 14.
RSC Med Chem. 2022.
PMID: 36545434
Free PMC article.
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Optimization of Class I Histone Deacetylase PROTACs Reveals that HDAC1/2 Degradation is Critical to Induce Apoptosis and Cell Arrest in Cancer Cells.
Smalley JP, Baker IM, Pytel WA, Lin LY, Bowman KJ, Schwabe JWR, Cowley SM, Hodgkinson JT.
Smalley JP, et al.
J Med Chem. 2022 Apr 14;65(7):5642-5659. doi: 10.1021/acs.jmedchem.1c02179. Epub 2022 Mar 16.
J Med Chem. 2022.
PMID: 35293758
Free PMC article.
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Comprehensive Transcriptomic Analysis of Novel Class I HDAC Proteolysis Targeting Chimeras (PROTACs).
Baker IM, Smalley JP, Sabat KA, Hodgkinson JT, Cowley SM.
Baker IM, et al. Among authors: smalley jp.
Biochemistry. 2023 Feb 7;62(3):645-656. doi: 10.1021/acs.biochem.2c00288. Epub 2022 Aug 10.
Biochemistry. 2023.
PMID: 35948047
Free PMC article.
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PROTAC-mediated degradation of class I histone deacetylase enzymes in corepressor complexes.
Smalley JP, Adams GE, Millard CJ, Song Y, Norris JKS, Schwabe JWR, Cowley SM, Hodgkinson JT.
Smalley JP, et al.
Chem Commun (Camb). 2020 Apr 21;56(32):4476-4479. doi: 10.1039/d0cc01485k.
Chem Commun (Camb). 2020.
PMID: 32201871
Free PMC article.
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MDM2 Antagonist Idasanutlin Reduces HDAC1/2 Abundance and Corepressor Partners but Not HDAC3.
Smalley JP, Cowley SM, Hodgkinson JT.
Smalley JP, et al.
ACS Med Chem Lett. 2023 Dec 6;15(1):93-98. doi: 10.1021/acsmedchemlett.3c00449. eCollection 2024 Jan 11.
ACS Med Chem Lett. 2023.
PMID: 38229760
Free PMC article.
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