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Physioxic human cell culture improves viability, metabolism, and mitochondrial morphology while reducing DNA damage.
FASEB J. 2019 Apr;33(4):5716-5728. doi: 10.1096/fj.201802279R. Epub 2019 Jan 16.
FASEB J. 2019.
PMID: 30649960
Analysis of Cap-binding Proteins in Human Cells Exposed to Physiological Oxygen Conditions.
Timpano S, Melanson G, Evagelou SL, Guild BD, Specker EJ, Uniacke J.
Timpano S, et al. Among authors: specker ej.
J Vis Exp. 2016 Dec 28;(118):55112. doi: 10.3791/55112.
J Vis Exp. 2016.
PMID: 28060265
Free PMC article.
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DEAD Box Protein Family Member DDX28 Is a Negative Regulator of Hypoxia-Inducible Factor 2α- and Eukaryotic Initiation Factor 4E2-Directed Hypoxic Translation.
Evagelou SL, Bebenek O, Specker EJ, Uniacke J.
Evagelou SL, et al. Among authors: specker ej.
Mol Cell Biol. 2020 Feb 27;40(6):e00610-19. doi: 10.1128/MCB.00610-19. Print 2020 Feb 27.
Mol Cell Biol. 2020.
PMID: 31907278
Free PMC article.
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Autophagy-dependent alternative splicing of ribosomal protein S24 produces a more stable isoform that aids in hypoxic cell survival.
Kerry J, Specker EJ, Mizzoni M, Brumwell A, Fell L, Goodbrand J, Rosen MN, Uniacke J.
Kerry J, et al. Among authors: specker ej.
FEBS Lett. 2024 Mar;598(5):503-520. doi: 10.1002/1873-3468.14804. Epub 2024 Jan 28.
FEBS Lett. 2024.
PMID: 38281767
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