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Page 1
Association of Statin Use With Risk of Liver Disease, Hepatocellular Carcinoma, and Liver-Related Mortality.
Vell MS, Loomba R, Krishnan A, Wangensteen KJ, Trebicka J, Creasy KT, Trautwein C, Scorletti E, Seeling KS, Hehl L, Rendel MD, Zandvakili I, Li T, Chen J, Vujkovic M, Alqahtani S, Rader DJ, Schneider KM, Schneider CV. Vell MS, et al. Among authors: creasy kt. JAMA Netw Open. 2023 Jun 1;6(6):e2320222. doi: 10.1001/jamanetworkopen.2023.20222. JAMA Netw Open. 2023. PMID: 37358849 Free PMC article.
A multiancestry genome-wide association study of unexplained chronic ALT elevation as a proxy for nonalcoholic fatty liver disease with histological and radiological validation.
Vujkovic M, Ramdas S, Lorenz KM, Guo X, Darlay R, Cordell HJ, He J, Gindin Y, Chung C, Myers RP, Schneider CV, Park J, Lee KM, Serper M, Carr RM, Kaplan DE, Haas ME, MacLean MT, Witschey WR, Zhu X, Tcheandjieu C, Kember RL, Kranzler HR, Verma A, Giri A, Klarin DM, Sun YV, Huang J, Huffman JE, Creasy KT, Hand NJ, Liu CT, Long MT, Yao J, Budoff M, Tan J, Li X, Lin HJ, Chen YI, Taylor KD, Chang RK, Krauss RM, Vilarinho S, Brancale J, Nielsen JB, Locke AE, Jones MB, Verweij N, Baras A, Reddy KR, Neuschwander-Tetri BA, Schwimmer JB, Sanyal AJ, Chalasani N, Ryan KA, Mitchell BD, Gill D, Wells AD, Manduchi E, Saiman Y, Mahmud N, Miller DR, Reaven PD, Phillips LS, Muralidhar S, DuVall SL, Lee JS, Assimes TL, Pyarajan S, Cho K, Edwards TL, Damrauer SM, Wilson PW, Gaziano JM, O'Donnell CJ, Khera AV, Grant SFA, Brown CD, Tsao PS, Saleheen D, Lotta LA, Bastarache L, Anstee QM, Daly AK, Meigs JB, Rotter JI, Lynch JA; Regeneron Genetics Center; Geisinger-Regeneron DiscovEHR Collaboration; EPoS Consortium; VA Million Veteran Program; Rader DJ, Voight BF, Chang KM. Vujkovic M, et al. Among authors: creasy kt. Nat Genet. 2022 Jun;54(6):761-771. doi: 10.1038/s41588-022-01078-z. Epub 2022 Jun 2. Nat Genet. 2022. PMID: 35654975 Free PMC article.
mTORC1 controls murine postprandial hepatic glycogen synthesis via Ppp1r3b.
Uehara K, Lee WD, Stefkovich M, Biswas D, Santoleri D, Garcia Whitlock A, Quinn W 3rd, Coopersmith T, Creasy KT, Rader DJ, Sakamoto K, Rabinowitz JD, Titchenell PM. Uehara K, et al. Among authors: creasy kt. J Clin Invest. 2024 Jan 30;134(7):e173782. doi: 10.1172/JCI173782. J Clin Invest. 2024. PMID: 38290087 Free PMC article.
Mimicking opioid analgesia in cortical pain circuits.
James JG, McCall NM, Hsu AI, Oswell CS, Salimando GJ, Mahmood M, Wooldridge LM, Wachira M, Jo A, Sandoval Ortega RA, Wojick JA, Beattie K, Farinas SA, Chehimi SN, Rodrigues A, Ejoh LL, Kimmey BA, Lo E, Azouz G, Vasquez JJ, Banghart MR, Creasy KT, Beier KT, Ramakrishnan C, Crist RC, Reiner BC, Deisseroth K, Yttri EA, Corder G. James JG, et al. Among authors: creasy kt. bioRxiv [Preprint]. 2024 Apr 29:2024.04.26.591113. doi: 10.1101/2024.04.26.591113. bioRxiv. 2024. PMID: 38746090 Free PMC article. Preprint.
Human OPRM1 and murine Oprm1 promoter driven viral constructs for genetic access to μ-opioidergic cell types.
Salimando GJ, Tremblay S, Kimmey BA, Li J, Rogers SA, Wojick JA, McCall NM, Wooldridge LM, Rodrigues A, Borner T, Gardiner KL, Jayakar SS, Singeç I, Woolf CJ, Hayes MR, De Jonghe BC, Bennett FC, Bennett ML, Blendy JA, Platt ML, Creasy KT, Renthal WR, Ramakrishnan C, Deisseroth K, Corder G. Salimando GJ, et al. Among authors: creasy kt. Nat Commun. 2023 Sep 13;14(1):5632. doi: 10.1038/s41467-023-41407-2. Nat Commun. 2023. PMID: 37704594 Free PMC article.
A missense variant in human perilipin 2 (PLIN2 Ser251Pro) reduces hepatic steatosis in mice.
Scorletti E, Saiman Y, Jeon S, Schneider CV, Buyco DG, Lin C, Himes BE, Mesaros CA, Vujkovic M, Creasy KT, Furth EE, Billheimer JT, Hand NJ, Kaplan DE, Chang KM, Tsao PS, Lynch JA, Dempsey JL, Harkin J, Bayen S, Conlon D, Guerraty M, Phillips MC, Rader DJ, Carr RM. Scorletti E, et al. Among authors: creasy kt. JHEP Rep. 2023 Oct 11;6(1):100902. doi: 10.1016/j.jhepr.2023.100902. eCollection 2024 Jan. JHEP Rep. 2023. PMID: 38074507 Free PMC article.
Omega-3 intake is associated with liver disease protection.
Vell MS, Creasy KT, Scorletti E, Seeling KS, Hehl L, Rendel MD, Schneider KM, Schneider CV. Vell MS, et al. Among authors: creasy kt. Front Public Health. 2023 Jul 19;11:1192099. doi: 10.3389/fpubh.2023.1192099. eCollection 2023. Front Public Health. 2023. PMID: 37538264 Free PMC article.
The common p.Ile291Val variant of ERLIN1 enhances TM6SF2 function and is associated with protection against MASLD.
Rendel MD, Vitali C, Creasy KT, Zhang D, Scorletti E, Huang H, Seeling KS, Park J, Hehl L, Vell MS, Conlon D, Hayat S; Regeneron Center; Phillips MC, Schneider KM, Rader DJ, Schneider CV. Rendel MD, et al. Among authors: creasy kt. Med. 2024 Aug 9;5(8):963-980.e5. doi: 10.1016/j.medj.2024.04.010. Epub 2024 May 21. Med. 2024. PMID: 38776916 Free article.
Aspirin is associated with a reduced incidence of liver disease in men.
Vell MS, Krishnan A, Wangensteen K, Serper M, Seeling KS, Hehl L, Rendel MD, Zandvakili I, Vujkovic M, Scorletti E, Creasy KT, Trautwein C, Rader DJ, Alqahtani S, Schneider KM, Schneider CV. Vell MS, et al. Among authors: creasy kt. Hepatol Commun. 2023 Sep 15;7(10):e0268. doi: 10.1097/HC9.0000000000000268. eCollection 2023 Oct 1. Hepatol Commun. 2023. PMID: 37708453 Free PMC article.
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